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Key Documents

G9910

Sigma-Aldrich

Sodium glycodeoxycholate

BioXtra, ≥97% (HPLC)

Sinonimo/i:

3α,12α-Dihydroxy-5β-cholan-24-oic acid N-(carboxymethyl)amide, Glycodeoxycholic acid sodium salt, Glycodesoxycholic acid, N-(3α,12α-Dihydroxy-24-oxocholan-24-yl)glycine

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About This Item

Formula empirica (notazione di Hill):
C26H42NNaO5
Numero CAS:
Peso molecolare:
471.61
Numero CE:
Numero MDL:
Codice UNSPSC:
12161900
ID PubChem:
NACRES:
NA.25

Descrizione

anionic

Livello qualitativo

Nome Commerciale

BioXtra

Saggio

≥97% (HPLC)

PM

471.61 g/mol

Impurezze

≤0.0025% Phosphorus (P)
≤0.1% Insoluble matter

CMC

2.1 mM

Solubilità

H2O: 0.1 M, clear to slightly hazy, colorless to almost colorless

Anioni in tracce

chloride (Cl-): ≤1%
sulfate (SO42-): ≤0.05%

Cationi in tracce

Al: ≤0.0005%
Ca: ≤0.011%
Cu: ≤0.0005%
Fe: ≤0.001%
K: ≤0.005%
NH4+: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.003%

Stringa SMILE

[Na].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(=O)NCC(O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C26H43NO5.Na.H/c1-15(4-9-23(30)27-14-24(31)32)19-7-8-20-18-6-5-16-12-17(28)10-11-25(16,2)21(18)13-22(29)26(19,20)3;;/h15-22,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);;/t15-,16-,17-,18+,19-,20+,21+,22+,25+,26-;;/m1../s1
BMYWWGPEKRLDGW-ZXMGEDLUSA-N

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Descrizione generale

Sodium glycodeoxycholate is a bile salt that can be used to form biomimicking environments.

Applicazioni

Sodium glycodeoxycholate has been used in a study to develop more similar mimetic intestinal fluids to physiological fluids than those developed by mixed bile salt systems (MBS). It has also been used in a study to investigate Ca2+ buffering capability of bile salt micelles.

Azioni biochim/fisiol

Induces apoptosis in hepatocytes; may induce DNA cleavage.

Altre note

Bile Salt

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves


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Hu-He Chen et al.
Guang pu xue yu guang pu fen xi = Guang pu, 30(3), 748-752 (2010-05-26)
In the present article, NaGDC was used to study the Ca(2+)-buffering capability of bile salt micelles. NaGDC is a naturally occurring bile salt which constitutes approximately 10 molar percent of bile salt composition in gallbladder. The authors selected glycine conjugated
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International Journal of Pharmaceutics, 422, 7-7 (2012)
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