G6171

Anti-Glial Fibrillary Acidic Protein Antibody

mouse monoclonal, G-A-5

• Sinonimo/i: Anti-GFAP
• Numero MDL: MFCD00145904
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Nome del prodotto: Anti-Glial Fibrillary Acidic Protein antibody, Mouse monoclonal, clone G-A-5, purified from hybridoma cell culture
• Origine biologica: mouse
• Livello qualitativo: 200
• Coniugato: unconjugated
• Forma dell’anticorpo: purified from hybridoma cell culture; purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: G-A-5, monoclonal
• Stato: buffered aqueous solution
• PM: antigen ~50 kDa
• Reattività contro le specie: rat, human, pig
• Concentrazione: ~1.0 mg/mL
• tecniche: immunocytochemistry: suitable; immunohistochemistry: suitable; indirect immunofluorescence: 2.5-5 μg/mL using alcohol-fixed sections of rat brain/cerebellum.; western blot: suitable
• Isotipo: IgG1
• N° accesso UniProt: P14136
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... GFAP(2670) ; mouse ... Gfap(14580) ; pig ... GFAP(396562) ; rat ... Gfap(24387)

Descrizione

Descrizione generale

Glial fibrillary acidic protein (GFAP) is intermediary filament present in astrocyte cells and is expressed in 10 different isoforms. It comprises of N-terminal head, central rod and C-terminal tail domains. GFAP is mapped to human chromosome 17q21.31.

Immunogeno

purified GFAP from pig spinal cord.

Applicazioni

Anti-Glial Fibrillary Acidic Protein antibody, Mouse monoclonal has been used in immunocytochemistry and in immunofluorescence.

Monoclonal Anti-Glial Fibrillary Acidic Protein antibody is suitable for use in western blot and indirect immunofluorescence 2.5-5 μg/mL using alcohol-fixed sections of rat brain/cerebellum). The antibody can also be used for immunoblot (approx. 50 kDa), immunohistochemistry (in paraformaldehyde-fixed, frozen rabbit brain sections) and immunocytochemistry.

Azioni biochim/fisiol

Glial fibrillary acidic protein or GFAP assembly has been implicated in mitotic remodeling of glial structures. Genetic mutations in GFAP have been associated with Alexander disease.

Microdeletion in glial fibrillary acidic protein (GFAP) gene locus is implicated in intellectual disability and facial dysmorphism in children. High levels of GFAP is associated with acute intracerebral haemorrhage.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable