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G1796

Sigma-Aldrich

Glycolide

≥99%

Sinonimo/i:

1,4-Dioxane-2,5-dione

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About This Item

Formula empirica (notazione di Hill):
C4H4O4
Numero CAS:
502-97-6
Peso molecolare:
116.07
Numero CE:
207-954-9
Numero MDL:
MFCD00081108
Codice UNSPSC:
12162002
ID PubChem:
329799848
NACRES:
NA.23

Livello qualitativo

200

Saggio

≥99%

Punto di fusione

82-86 °C (lit.)

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

O=C1COC(=O)CO1

InChI

1S/C4H4O4/c5-3-1-7-4(6)2-8-3/h1-2H2
RKDVKSZUMVYZHH-UHFFFAOYSA-N

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Categorie correlate

Descrizione generale

Glycolide is a cyclic dimer of α-hydroxy acid that can be used in the formation of aliphatic polyester. It is synthesized by the dimerization of glycolic acid. It forms a low toxic synthetic biodegradable polymer that can be used in medical applications. It is majorly used in the formation of a highly crystalline poly(glycolide) by ring opening polymerization.

Applicazioni

Glycolide can be used as a monomer in the preparation of poly(lactic-co-glycolide)(PGLA) via copolymerization with lactide monomer. PGLA is further used in the following applications:
  • Porous PGLA microsphere scaffolds are used in bone repair applications.
  • Encapsulated PGLA nanoparticles can be used in drug delivery and tissue engineering applications. Polymeric micro/nanoparticles made from PLGA have gained significant interest for their appealing characteristics, including biodegradability, biocompatibility, prolonged drug release, and safeguarding the drug against degradation.
It can also be used to synthesize poly(glycolide-caprolactone)(PGCL) copolymers applicable as bioabsorbable suture materials.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H319

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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Sigma-Aldrich

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Sigma-Aldrich

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1,3-DIOXAN-2-ONE AldrichCPR

S939668

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Poly(caprolactone-co-glycolide) 40:60, viscosity 1.6 dL/g 

Sigma-Aldrich

901011

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Sigma-Aldrich

389579

δ-Valerolactone

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Introduction of Bioplastic Engineering, 81-151 (2016)
J L Guo et al.
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