G0500
D-(+)-Galactosamine hydrochloride
≥99% (HPLC)
Sinonimo/i:
2-Amino-2-deoxy-D-galactopyranose hydrochloride, D-Chondrosamine hydrochloride
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About This Item
Formula empirica (notazione di Hill):
C6H13NO5 · HCl
Numero CAS:
Peso molecolare:
215.63
Beilstein:
3697825
Numero CE:
Numero MDL:
Codice UNSPSC:
12352201
ID PubChem:
NACRES:
NA.25
Prodotti consigliati
Livello qualitativo
Saggio
≥99% (HPLC)
Stato
powder
tecniche
HPLC: suitable
Impurezze
≤0.5% Glucosamine (HPAE)
Colore
white to off-white
Punto di fusione
172-180 °C
Solubilità
H2O: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow
Temperatura di conservazione
room temp
Stringa SMILE
Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO
InChI
1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1
CBOJBBMQJBVCMW-NQZVPSPJSA-N
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Descrizione generale
D-galactosamine (d-GalN) is a specific hepatotoxic agent metabolized particularly in hepatocytes. It is a 6-carbon amino sugar derived from galactose.
Applicazioni
D-(+)-Galactosamine (D-chondrosamine) has been used with lipopolysaccharides (LPS) to induce models of acute hepatic failure (LPS/D-GalN-induced liver injury, hepatitis) for therapeutic research to find new drugs.
D-(+)-Galactosamine hydrochloride has been used:
- for the surface binding of mannan-binding lectin (MBL) to modified mica surfaces
- in sterile phosphate buffer saline (PBS) before the intraperitoneal injection
- in mice for the generation of primary bone marrow-derived macrophages (BMDMs)
Azioni biochim/fisiol
Galactosamine (Gal) induces hepatocyte death both by necrosis and apoptosis. It prevents the production of liver RNA via the production of uridine diphosphate hexosamines. D-galactosamine lowers the intracellular pool of uracil nucleotides and thereby prevents the production of RNA and proteins.
Altre note
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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I clienti hanno visto anche
Xing Lin et al.
Biological & pharmaceutical bulletin, 37(4), 625-632 (2014-05-13)
This study examined the effect of genistein from Hydrocotyle sibthorpioides on lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced acute hepatic failure. Compared to the model control, genistein treatment significantly protected against LPS/D-GalN-induced liver injury, as evidenced by the decrease in serum alanine and aspartate
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