F8180
FMS (539-end), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinonimo/i:
C-FMS, CD115, CSF1R, CSFR, FIM2
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About This Item
Codice UNSPSC:
12352200
NACRES:
NA.32
Prodotti consigliati
Ricombinante
expressed in baculovirus infected Sf9 cells
Livello qualitativo
Nome Commerciale
PRECISIO® Kinase
Saggio
≥70% (SDS-PAGE)
Forma fisica
buffered aqueous glycerol solution
Attività specifica
18-24 nmol/min·mg
PM
~76 kDa
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... CSF1R(1436)
Descrizione generale
FMS, also called CSF1R colony stimulating factor 1 receptor, acts as a receptor for CSF1, and they both as key regulators of monocyte and macrophage functioning. It is a member of the platelet-derived growth factor (PDGF) family of proteins, and is a type III RTK (receptor tyrosine kinase). It is composed of five immunoglobulin (Ig)-like domains, a transmembrane region, a juxtamembrane domain, and kinase insert domain (KID) intersecting the kinase domain.
Azioni biochim/fisiol
FMS also called CSF1R colony stimulating factor 1 receptor, and its ligand CSF1 are linked to poor prognosis in patients with solid tumors, and in patients with female reproductive cancers. In breast cancers with decreased claudin levels, this protein regulates the switch between proliferative and invasive state of the tumor, acting downstream of TGFβ (tumor growth factor β). Haploinsufficiency in this receptor might lead to aberration of microglial function, which might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).
Stato fisico
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Note legali
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificati d'analisi (COA)
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George Alexander Follows et al.
Oncogene, 24(22), 3643-3651 (2005-04-05)
The macrophage colony-stimulating factor receptor is encoded by the c-FMS gene, and it has been suggested that altered regulation of c-FMS expression may contribute to leukaemic transformation. c-FMS is expressed in pluripotent haemopoietic precursor cells and is subsequently upregulated during
C J Sherr
International journal of cell cloning, 8 Suppl 1, 46-60 (1990-01-01)
Colony-stimulating factor-1 (CSF-1 or M-CSF) regulates pleiotropic developmental and functional responses of macrophages and their committed bone marrow progenitors and supports the viability of cells of the mononuclear phagocyte lineage. Its actions are mediated through its binding to cell surface
Hang Liu et al.
Breast cancer research and treatment, 166(1), 95-107 (2017-07-22)
Endocrine resistance limits the efficacy of anti-estrogen therapies. Notch signaling is involved in modulating tumor-associated macrophage (TAM) differentiation and is upregulated in endocrine-resistant breast cancer cells. Here, we analyzed the role of Jagged1 in the regulation of TAM polarization to
Takuya Konno et al.
Neurology, 82(2), 139-148 (2013-12-18)
To clarify the genetic, clinicopathologic, and neuroimaging characteristics of patients with hereditary diffuse leukoencephalopathy with spheroids (HDLS) with the colony stimulating factor 1 receptor (CSF-1R) mutation. We performed molecular genetic analysis of CSF-1R in patients with HDLS. Detailed clinical and
A Patsialou et al.
Oncogene, 34(21), 2721-2731 (2014-08-05)
Patient data suggest that colony-stimulating factor-1 (CSF1) and its receptor (CSF1R) have critical roles during breast cancer progression. We have previously shown that in human breast tumors expressing both CSF1 and CSF1R, invasion in vivo is dependent both on a
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