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Key Documents

F4641

Sigma-Aldrich

Anti-Human IgG3−FITC antibody, Mouse monoclonal

clone HP-6050, purified from hybridoma cell culture

Sinonimo/i:

Monoclonal Anti-Human IgG3

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.46

Origine biologica

mouse

Livello qualitativo

Coniugato

FITC conjugate

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

secondary antibodies

Clone

HP-6050, monoclonal

Forma fisica

buffered aqueous solution

Condizioni di stoccaggio

protect from light

tecniche

dot immunobinding: 1:64
particle immunofluorescence: 1:8

Isotipo

IgG1

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

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Descrizione generale

Human Immunoglobulin G consists of four subclasses, namely IgG1, IgG2, IgG3, and IgG4, named γ1, γ2, γ3, and γ4, respectively. The primary structure of the antibody contains disulfide bonds involved in linking the two heavy chains,and linking the heavy and light chains. IgG3, a pro-inflammatory antibody, appears first in the course of a viral infection and induces effector functions.

Specificità

The antibody is specific for human IgG3 and is non-reactive with other IgG subclasses. This clone has been recommended by the IUIS/WHO study for its specificity and reactivity in a wide range of assay protocols and techniques.

Applicazioni

Monoclonal Anti-Human IgG3-FITC antibody produced in mouse has been used in immunohistochemistry and indirect immunofluorescence.

Stato fisico

Solution in 0.01 M phosphate buffer, pH 8.0, containing 1% inactivated bovine serum albumin and 15 mM sodium azide.

Stoccaggio e stabilità

For continuous use, store at 2-8 °C for up to one month.
For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.

Altre note

In order to obtain best results, it is recommended that each individual user determine working dilutions by titration assay.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


Certificati d'analisi (COA)

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Seroprevalence of human herpesvirus 6 in Andino Pune?os (Argentina)
Romagnoli, Pablo Alberto, et al.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 669-672 (2000)
Erdem Tüzün et al.
Acta neuropathologica, 118(6), 737-743 (2009-08-15)
We report the immunopathological analysis of the brain and tumor of two patients who died of anti-NMDAR-associated encephalitis, and of the tumor of nine patients who recovered. Findings included prominent microgliosis and deposits of IgG with rare inflammatory infiltrates in
IgG Subclasses and Allotypes: From Structure to Effector Functions
Gestur V, et al.
Frontiers in Immunology (2014)
Antibody structure, instability, and formulation.
Wang W, et al.
Journal of Pharmaceutical Sciences, 96(1), 1-26 (2007)
Constance Manso et al.
The Journal of clinical investigation, 129(6), 2222-2236 (2019-03-15)
Neurofascin-155 (Nfasc155) is an essential glial cell adhesion molecule expressed in paranodal septate-like junctions of peripheral and central myelinated axons. The genetic deletion of Nfasc155 results in the loss of septate-like junctions and in conduction slowing. In humans, IgG4 antibodies

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