D4628

Diethylstilbestrol

≥99% (HPLC)

• Sinonimo/i: (E)-3,4-Bis(4-hydroxyphenyl)-3-hexene, DES, Stilbestrol
• Formula empirica (notazione di Hill): C₁₈H₂₀O₂
• Numero CAS: 56-53-1
• Peso molecolare: 268.35
• Beilstein: 2056095
• Numero CE: 200-278-5
• Numero MDL: MFCD00002373
• Codice UNSPSC: 51111800
• ID PubChem: 24893887
• NACRES: NA.77

Proprietà

• Livello qualitativo: 200
• Saggio: ≥99% (HPLC)
• Stato: powder
• Stringa SMILE: CC\C(c1ccc(O)cc1)=C(\CC)c2ccc(O)cc2
• InChI: 1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+; RGLYKWWBQGJZGM-ISLYRVAYSA-N
• Informazioni sul gene: human ... ESR1(2099) , ESR2(2100) , ESRRG(2104) ; mouse ... Esr1(13982) ; rat ... Ar(24208) , Esr1(24890)

Descrizione

Applicazioni

Diethylstilbestrol has been used:

• to evaluate the estrogenic activity of diethylstilbestrol by quantitating the expression levels of endogenous estrogen-regulated marker genes
• to evaluate the estrogenic, androgenic and toxicity responses in bioluminescent yeast bioreporter assay (BLYES)
• to detect its effect on the proliferation and tyrosinase activity of melanocytes

Azioni biochim/fisiol

Diethylstilbestrol is a synthetic estrogen with carcinogenic properties. Causes renal clear-cell carcinoma in Syrian hamster. In humans it causes increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive anomalies. Used in the treatment of prostate cancer to block the production of testosterone.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H315,H319,H335,H350,H360FD,H410
• Consigli di prudenza: P202 - P261 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges