D2534

cis-4,7,10,13,16,19-Docosahexaenoic acid

≥98%

• Sinonimo/i: DHA
• Formula empirica (notazione di Hill): C₂₂H₃₂O₂
• Numero CAS: 6217-54-5
• Peso molecolare: 328.49
• Beilstein: 1715505
• Numero MDL: MFCD00065722
• Codice UNSPSC: 12352211
• ID PubChem: 24893696
• NACRES: NA.25

Proprietà

• Origine biologica: algae
• Saggio: ≥98%
• Stato: liquid
• Gruppo funzionale: carboxylic acid
• Tipo di lipide: omega FAs
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O
• InChI: 1S/C22H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16,18-19H,2,5,8,11,14,17,20-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-,19-18-; MBMBGCFOFBJSGT-KUBAVDMBSA-N

Descrizione

Descrizione generale

Docosahexaenoic acid (DHA) is abundantly present in the brain.

Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid with 22 carbons and six double bonds, the first double bond occurring at position three from the methyl terminus (22:6 n-3). It is a component of lipid membranes and myelin sheath.

Applicazioni

cis-4,7,10,13,16,19-Docosahexaenoic acid has been used:

• as a component in Dulbecco′s modified Eagle medium (DMEM) for culturing cells to perform docosahexaenoic acid (DHA) treatment
• to study its impact on human induced pluripotent stem cell (iPSC)-derived neuronal at a molecular and cellular level
• in MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay to study its cytotoxic effects on three human hepatocellular carcinoma (HCC) cell lines (HepG2, Hep3B, Huh7)

Azioni biochim/fisiol

Docosahexaenoic acid (DHA) participates in the growth and physiology of the central nervous system. It regulates adult neurogenesis and neuroplasticity. DHA plays a key role in fetal brain development. It may exhibit antioxidant and anti-inflammatory properties. DHA plays a role in the regulation of cell membrane fluidity. It plays a vital role in several brain development processes, including neurotransmitter release, gene expression, myelination, neuroinflammation, and neuronal differentiation. DHA possesses an anticancer effect in several types of cancer.

Docosahexaenoic acid (DHA) serves as a precursor for signaling molecules such as prostaglandins and eicosanoids.

Confezionamento

Sealed ampule.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): 143.6 °F - closed cup
• Punto d’infiammabilità (°C): 62 °C - closed cup
• Dispositivi di protezione individuale: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)