D0899

Diazepam

≥98% (TLC), powder, GABAA receptor ligand

• Sinonimo/i: 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one, Ro 5-2807
• Formula empirica (notazione di Hill): C₁₆H₁₃ClN₂O
• Numero CAS: 439-14-5
• Peso molecolare: 284.74
• Numero CE: 207-122-5
• Numero MDL: MFCD00057323
• Codice UNSPSC: 12352200
• ID PubChem: 24893306
• NACRES: NA.77

Proprietà

• product name: Diazepam,
• Forma fisica: powder
• Controllo stupefacenti: USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• Solubilità: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.6 mg/mL; DMF: soluble; H₂O: slightly soluble; ethanol: soluble
• Ideatore: Roche
• Stringa SMILE: CN1C(=O)CN=C(c2ccccc2)c3cc(Cl)ccc13
• InChI: 1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3; AAOVKJBEBIDNHE-UHFFFAOYSA-N
• Informazioni sul gene: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879) ; rat ... Gabra1(29705) , Gabra2(29706)

Descrizione

Applicazioni

Diazepam has been used:

• as an anxiolyte in pilocarpine protocol.
• in multi-electrode array (MEA) technology
• as a marker for human serum albumin

Azioni biochim/fisiol

Diazepam is a benzodiazepine anxiolytic agent. It serves as a prototype ligand for the GABAA receptor benzodiazepine modulatory site.

Diazepam is often used as a sedative. Its metabolism involves cytochrome P450 (CYP) 2C19 and 3A4. Diazepam has immediate action upon administration.

Caratteristiche e vantaggi

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H301 + H311,H410
• Consigli di prudenza: P264 - P273 - P280 - P301 + P310 - P302 + P352 + P312 - P361 + P364
• Classi di pericolo: Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 1
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves