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Key Documents

C9755

Sigma-Aldrich

Cytidine 5′-diphosphate sodium salt hydrate

from yeast, ≥95%

Sinonimo/i:

CDP sodium salt hydrate

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About This Item

Formula empirica (notazione di Hill):
C9H15N3O11P2
Peso molecolare:
403.18
Numero MDL:
Codice UNSPSC:
41106305
ID PubChem:
NACRES:
NA.51

Origine biologica

yeast

Saggio

≥95%

Forma fisica

powder

Temperatura di conservazione

−20°C

Stringa SMILE

[Na].NC1=NC(=O)N(C=C1)C2OC(COP(O)(=O)OP(O)(O)=O)C(O)C2O

InChI

1S/C9H15N3O11P2.Na.H/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18);;
MAGSIBHRUIBONY-UHFFFAOYSA-N

Categorie correlate

Descrizione generale

Cytidine 5′-diphosphate (CDP) is synthesized from cytidine monophosphate (CMP) or uridine monophosphate (UMP) by the transfer of phosphoryl group, catalyzed by the enzyme uridylate kinase (UMPK). CTP synthetase catalyzes the conversion of CTP to CDP intermediates like CDP-diacylglycerol, CDP-choline and CDP-ethanolamine for phospholipid biosynthesis.

Applicazioni

Cytidine 5′-diphosphate sodium salt hydrate has been used:
  • as a substrate in nucleoside diphosphatase (NDPase) enzyme histochemistry assay of gold fish eye sections
  • in ribonucleotide reductase assay
  • dCDP formation assay.

Azioni biochim/fisiol

Cytidine 5′-diphosphate (CDP) is used as a substrate of nucleoside diphosphatase kinase to produce CTP for supporting DNA and RNA biosynthesis and of ribonucleotide reductase to product dCMP.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


Certificati d'analisi (COA)

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Purine and pyrimidine nucleotide synthesis and metabolism
The Arabidopsis Book / American Society of Plant Biologists, 1 (2002)
Ribonucleotide reductase requires subunit switching in hypoxia to maintain DNA replication
Foskolou IP, et al.
Molecular Cell, 66(2), 206-220 (2017)
CTP synthetase and its role in phospholipid synthesis in the yeast Saccharomyces cerevisiae
Chang YF and Carman GM
Progress in Lipid Research, 47(5), 333-339 (2008)
Yan Zhang et al.
Biochemistry, 50(25), 5615-5623 (2011-05-13)
Bacillus subtilis class Ib ribonucleotide reductase (RNR) catalyzes the conversion of nucleotides to deoxynucleotides, providing the building blocks for DNA replication and repair. It is composed of two proteins: α (NrdE) and β (NrdF). β contains the metallo-cofactor, essential for
Microglial cells in the retina of Carassius auratus: effects of optic nerve crush
Salvador-Silva M, et al.
The Journal of Comparative Neurology, 417(4), 431-447 (2000)

Protocolli

ZIC-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

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