C9393

Cloxacillin sodium salt monohydrate

β-lactamase-resistant antibiotic

• Sinonimo/i: Cloxacillin, Sodium cloxacillin monohydrate
• Formula condensata: C₁₉H₁₇ClN₃O₅SNa · H₂O
• Numero CAS: 7081-44-9
• Peso molecolare: 475.88
• Numero CE: 211-390-9
• Numero MDL: MFCD00150735
• Codice UNSPSC: 51102829
• ID PubChem: 24893156
• NACRES: NA.85

Proprietà

• Livello qualitativo: 200
• Stato: powder or crystals
• Spettro attività antibiotica: Gram-positive bacteria
• Modalità d’azione: cell wall synthesis | interferes
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O.[Na+].Cc1onc(-c2ccccc2Cl)c1C(=O)N[C@H]3[C@H]4SC(C)(C)[C@@H](N4C3=O)C([O-])=O
• InChI: 1S/C19H18ClN3O5S.Na.H2O/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1; KCUWTKOTPIUBRI-VICXVTCVSA-M

Descrizione

Descrizione generale

Chemical structure: ß-lactam

Applicazioni

Cloxacillin is effective against infections caused by penicillin G-resistant staphylococci. It was used in studies of topical antibacterial agents for burn and crush wounds.

Azioni biochim/fisiol

Cloxacillin is a semi-synthetic antibiotic and a chlorinated derivative of oxacillin. It inhibits the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Cloxacillin is often used as AmpC β-lactamase inhibitor in combination with β-lactam antibiotics.

Altre note

Keep container tightly closed in a dry and well-ventilated place.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H315,H317,H319,H334,H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Faceshields, Gloves