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C8655

Sigma-Aldrich

4-Chloro-L-phenylalanine

Sinonimo/i:

L-PCPA

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About This Item

Formula condensata:
ClC6H4CH2CH(NH2)CO2H
Numero CAS:
14173-39-8
Peso molecolare:
199.63
Beilstein:
2416150
Numero CE:
238-023-5
Numero MDL:
MFCD00063065
Codice UNSPSC:
12352209
eCl@ss:
32160406
ID PubChem:
24893091
NACRES:
NA.32

Forma fisica

powder

Punto di fusione

263 °C (dec.) (lit.)

Temperatura di conservazione

−20°C

Stringa SMILE

N[C@@H](Cc1ccc(Cl)cc1)C(O)=O

InChI

1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m0/s1
NIGWMJHCCYYCSF-QMMMGPOBSA-N

Informazioni sul gene

human ... TPH1(7166) , TPH2(121278)
mouse ... TPH1(21990) , TPH2(216343)
rat ... TPH1(24848) , TPH2(317675)

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Applicazioni

4-Chloro-L-phenylalanine (L-PCPA) has been used:
  • to block serotonin synthesis by inhibiting tryptophan hydroxylase (TPH)
  • to study its behavioral and electrographic effects on epileptic senegalese baboon (Papio papio)
  • as a substrate for Chromobacterium violaceum phenylalanine hydroxylase
  • to incubate sea urchin embryos for immunohistochemistry

Azioni biochim/fisiol

4-Chloro-L-phenylalanine (L-PCPA) inhibits the synthesis of 5-hydroxytryptamine (5-HT). 4-Chloro-DL-phenylalanine (PCPA) depletes the serotonin levels in the brain by its inhibitory effect on tryptophan hydroxylase (Tph). Studies support the protective effects of PCPA against monocrotaline-induced pulmonary vascular remodeling as well as in lung inflammation.
Tryptophan hydroxylase inhibitor.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Prodotti correlati

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H9772

5-Hydroxy-L-tryptophan, powder

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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