C3635
4-Chloro-DL-phenylalanine methyl ester hydrochloride
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About This Item
Formula condensata:
ClC6H4CH2CH(NH2)CO2CH3·HCl
Numero CAS:
Peso molecolare:
250.12
Numero CE:
Numero MDL:
Codice UNSPSC:
12352209
ID PubChem:
NACRES:
NA.32
Prodotti consigliati
Stato
powder
Livello qualitativo
Punto di fusione
186-189 °C (lit.)
Temperatura di conservazione
−20°C
Stringa SMILE
Cl.COC(=O)C(N)Cc1ccc(Cl)cc1
InChI
1S/C10H12ClNO2.ClH/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7;/h2-5,9H,6,12H2,1H3;1H
GCBCWTWQAFLKJG-UHFFFAOYSA-N
Informazioni sul gene
human ... TPH1(7166) , TPH2(121278)
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Descrizione generale
4-Chloro-DL-phenylalanine methyl ester hydrochloride stimulates glucose intolerance in pregnant mice. Studies have shown that 4-Chloro-DL-phenylalanine methyl ester hydrochloride is associated with cognitive defects in rodents.
Applicazioni
4-Chloro-DL-phenylalanine methyl ester hydrochloride has been used to induce 5-hydroxytryptamine (5-HT) depletion in rats.
Azioni biochim/fisiol
Tryptophan hydroxylase inhibitor. Crosses blood brain barrier better than p−chlorophenylalanine.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Jessica E Monk et al.
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Kim H, et al.
Nature Medicine, 16(7), 804-804 (2010)
Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus
Kornum BR, et al.
Brain Research, 1073, 262-268 (2006)
Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: a potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism
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