C7736
Anti-Centrin antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinonimo/i:
Anti-CEN1, Anti-CETN
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About This Item
Prodotti consigliati
Origine biologica
rabbit
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
buffered aqueous solution
PM
antigen 21 kDa
Reattività contro le specie
human
tecniche
microarray: suitable
western blot: 1:2,000 using 293-T exp.Hu.Centrin-1LY117608 or 293-T exp.Hu.Centrin1-FLAG LY401316
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... CETN1(1068)
Descrizione generale
Centrins are acidic proteins, that are usually found in all eukaryotes. Centrin 1 (CETN1), an intron-less gene is mapped on human chromosome 18p11. It possesses certain features of an expressed retroposon.
The centrosome, the major microtubule-organizing center (MTOC) in the animal cell, is a key determinant in the organization of the cytoplasm, in the determination of cell polarity, and in the establishment of mitotic spindle poles during the cell cycle. Centrin is a member of the calcium binding E-F hand protein superfamily present in the centrosome pericentriolar matrix.
Three separate centrin genes have been identified in human cells: centrin 1, 2, and 3. Centrin 1 shows strong amino acid homology to centrin 2 (85%), but lower homology to centrin 3 (54%) and CDC31 (50%) from the yeast S. cerevisiae. Centrin has a fundamental role in the MTOC structure and function. Phenotypic analysis of mutants in Chlamydomonas caltractin and the yeast CDC31 genes have indicated that the protein is required for proper duplication and segregation of the MTOC in the respective cells.
Three separate centrin genes have been identified in human cells: centrin 1, 2, and 3. Centrin 1 shows strong amino acid homology to centrin 2 (85%), but lower homology to centrin 3 (54%) and CDC31 (50%) from the yeast S. cerevisiae. Centrin has a fundamental role in the MTOC structure and function. Phenotypic analysis of mutants in Chlamydomonas caltractin and the yeast CDC31 genes have indicated that the protein is required for proper duplication and segregation of the MTOC in the respective cells.
Immunogeno
synthetic peptide corresponding to the C-terminus of human centrin 1 (amino acids 157-172). The sequence is highly conserved in centrin 1 of many species, e.g. mouse, Drosophila, and Xenopus. It is also found in human and mouse centrin 2, but is not found in centrin 3.
Applicazioni
Anti-Centrin antibody produced in rabbit has been used in:
- immunofluorescence
- immunoblotting
- immunofluorescence microscopy
Azioni biochim/fisiol
Centrin has a fundamental role in the microtubule-organizing center (MTOC) structure and function. These proteins has imperative roles in centrosome positioning and segregation. Centrin also participates in cytokinesis and cell cycle progression.
Stato fisico
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Raccomandato
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Asterless is a scaffold for the onset of centriole assembly
Dzhindzhev NS, et al.
Nature, 467(7316), 714-718 (2010)
DNA Damage-Induced Accumulation of Centrosomal Chk1 Contributes to its Checkpoint Function
Looffler H, et al.
Cell Cycle, 6(20), 2541-2548 (2007)
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Phanindranath R, et al.
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