C3019

Coenzyme A trilithium salt

≥93%

• Sinonimo/i: CoA Li₃
• Formula empirica (notazione di Hill): C₂₁H₃₃Li₃N₇O₁₆P₃S
• Numero CAS: 18439-24-2
• Peso molecolare: 785.33
• Numero CE: 242-317-9
• Numero MDL: MFCD00075848
• Codice UNSPSC: 41106305
• ID PubChem: 24892557
• NACRES: NA.51

Proprietà

• Livello qualitativo: 200
• Saggio: ≥93%
• Stato: powder
• Temperatura di conservazione: −20°C
• Stringa SMILE: [Li+].[Li+].[Li+].CC(C)(COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
• InChI: 1S/C21H36N7O16P3S.3Li/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;;;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);;;/q;3*+1/p-3/t11-,14-,15-,16?,20-;;;/m1.../s1; QSCBPHBAFBVXRK-HJKJOZROSA-K

Descrizione

Descrizione generale

Coenzyme A (CoA) is synthesized from phosphopantothenate by the action of enzyme pantothenate kinase and is the master regulator.

Applicazioni

Coenzyme A trilithium salt has been used:

• in standard curve generation in the kinetic assay of acetyltransferase Gcn5 acylation
• as a cofactor in JNADH and JNADPH production assay
• in the labeling of Alexa647 (AF647) probe

Azioni biochim/fisiol

Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes. Acyl CoA accumulation is implicated in metabolic disorders and may indirectly lead to the pathogenesis associated with carbon-induced mitochondrial stress heart failure, diabetes and obesity.

Altre note

For more more technical information and a complete list of Coenzyme A deriviatives visit the Acyl Transfer Reagents Resource.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)