C2240
Anti-Calcium Channel CaV3.1 (α1G) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
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About This Item
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
lyophilized powder
Reattività contro le specie
rat
tecniche
western blot: 1:200 using rat brain membranes
N° accesso UniProt
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... CACNA1G(8913)
rat ... Cacna1g(29717)
Categorie correlate
Descrizione generale
Calcium channel, voltage-dependent, T type, α 1G subunit is a protein encoded by CACNA1G gene in humans. It belongs to a family of voltage-gated calcium channels and serves as the key transducer of cell surface membrane potential changes into local intracellular calcium transients that initiate many different physiological events.
Immunogeno
peptide corresponding to amino acid residues 1-22 of rat CaV3.1. This epitope is highly homologous in human (20/22 residues identical).
Applicazioni
Anti-Calcium Channel CaV3.1 (α1G) antibody produced in rabbit is suitable for western blotting at a dilution of 1:200 using rat brain membranes.
Azioni biochim/fisiol
CACNA1G (T-type channels) are involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance and rebound burst firing. It exhibits a significant window current that helps for Fe2+ pathway entry into cells with relevant concentrations of extracellular Fe2+. The window current also creates a pathway for Cd2+ entry into cells during Cd2+ exposure. CACNA1G were found to be associated with Autism Spectrum Disorder.
Stato fisico
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Prodotti correlati
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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E Perez-Reyes et al.
Nature, 391(6670), 896-900 (1998-03-12)
The molecular diversity of voltage-activated calcium channels was established by studies showing that channels could be distinguished by their voltage-dependence, deactivation and single-channel conductance. Low-voltage-activated channels are called 'T' type because their currents are both transient (owing to fast inactivation)
S P Strom et al.
Molecular psychiatry, 15(10), 996-1005 (2009-05-21)
Chromosome 17q11-q21 is a region of the genome likely to harbor susceptibility to autism (MIM(209850)) based on earlier evidence of linkage to the disorder. This linkage is specific to multiplex pedigrees containing only male probands (MO) within the Autism Genetic
Kyle V Lopin et al.
Molecular pharmacology, 82(6), 1194-1204 (2012-09-14)
Iron is a biologically essential metal, but excess iron can cause damage to the cardiovascular and nervous systems. We examined the effects of extracellular Fe²⁺ on permeation and gating of Ca(V)3.1 channels stably transfected in HEK293 cells, by using whole-cell
William A Catterall et al.
Pharmacological reviews, 57(4), 411-425 (2005-12-31)
The family of voltage-gated calcium channels serves as the key transducers of cell surface membrane potential changes into local intracellular calcium transients that initiate many different physiological events. There are 10 members of the voltage-gated calcium channel family that have
Kyle V Lopin et al.
Molecular pharmacology, 82(6), 1183-1193 (2012-09-14)
Cd²⁺ is an industrial pollutant that can cause cytotoxicity in multiple organs. We examined the effects of extracellular Cd²⁺ on permeation and gating of Ca(v)3.1 (α1G) channels stably transfected in HEK293 cells, by using whole-cell recording. With the use of
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