Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

View All Documentation

C2175

Sigma-Aldrich

(Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide

≥97% (HPLC), powder

Sinonimo/i:

CCK-8, Cholecystokinin octapeptide, Pancreozymin C-terminal octapeptide, Sincalide

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C49H62N10O16S3
Numero CAS:
25126-32-3
Peso molecolare:
1143.27
Beilstein:
5231801
Numero CE:
246-639-0
Numero MDL:
MFCD00079849
Codice UNSPSC:
51111800
ID PubChem:
24892470
NACRES:
NA.32

Livello qualitativo

200

Saggio

≥97% (HPLC)

Forma fisica

powder

N° accesso UniProt

P06307
P30551
P30553

Temperatura di conservazione

−20°C

Stringa SMILE

CSCC[C@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@@H](N)CC(O)=O)C(=O)NCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NC(CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O

InChI

1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35?,36-,37-,38-,39-/m0/s1
IZTQOLKUZKXIRV-IVVJSLGPSA-N

Informazioni sul gene

human ... CCK(885)
rat ... Cckar(24889) , Cckbr(25706)

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Amino Acid Sequence

Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2

Descrizione generale

(Tyr[SO3H]27)Cholecystokinin fragment 26-33 amide is a sulfated cholecystokinin(CCK) octapeptide derived from the proCCK. It is present in plasma and endocrine cells.

Applicazioni

(Tyr[SO3H]27)Cholecystokinin fragment 26-33 amide has been used to test its effects:
  • to study its effects on β5i/LMP7 immunoproteasome subunit in pancreatitis
  • on gastric emptying,food intake and c-Fos immunoreactivity in small litter (SL) and normal litter (NL) rats
  • on the intestine and gallbladder motility in fish Ballan Wrasse

Azioni biochim/fisiol

(Tyr[SO3H]27)Cholecystokinin fragment 26-33 amide activates the cholecystokinin type B receptor and may mediate the blockage of opioid analgesia. It elicits anti-inflammatory effects. It mediates the inhibition on cytokine release, lymphocytes, and macrophages.
Neurotransmitter; predominant form of CCK in CNS and gastrointestinal tract; may play a role in satiety.

Altre note

C-Terminal octapeptide of cholecystokinin

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Chunyong Han et al.
Aging, 11(14), 4858-4875 (2019-07-17)
Long non-coding RNAs (lncRNAs) regulate cancer development and progression. Here, we investigated the role of the lncRNA CCAT1 in triple-negative breast cancer (TNBC). CCAT1 expression was higher in TNBC cells than normal breast epithelial cells. Additionally, CCAT1 expression was higher
Yan Huang et al.
Materials science & engineering. C, Materials for biological applications, 103, 109748-109748 (2019-07-28)
It is well known that the differentiation of stem cells is affected by the cell culture medium, the scaffold surface and electrochemical signals. However, stimulation of patterned biomaterials seeded with stem cell cultures has not been explored. Herein the effect
J-X Li et al.
European review for medical and pharmacological sciences, 23(15), 6411-6418 (2019-08-06)
To explore the regulatory role of PLZF in the malignant phenotype of non-APL acute myeloid leukemia (AML) and its underlying mechanism. The expression level of PLZF in AML cell lines KG-1a, HL-60, OCI-AML3, THP-1 and K562 was detected by quantitative
Preparation and optimization of a gelatin-based biomimetic three-layered vascular scaffold.
Qingxi Hu et al.
Journal of biomaterials applications, 34(3), 431-441 (2019-05-28)
Yong Bai et al.
Cell cycle (Georgetown, Tex.), 18(18), 2323-2331 (2019-08-06)
Long non-coding RNAs (lncRNAs) are key mediators of cancer. The dysregulation of a lncRNA, CASC15, has been linked to several cancers, except lung cancer. Here, the aim of the study was to explore the role and mechanism of CASC15 in
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.