C1159
L-Cycloserine
Sinonimo/i:
(S)-4-Amino-3-isoxazolidone
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About This Item
Formula empirica (notazione di Hill):
C3H6N2O2
Numero CAS:
Peso molecolare:
102.09
Beilstein:
80799
Numero CE:
Numero MDL:
Codice UNSPSC:
12352202
eCl@ss:
32160406
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Saggio
≥95% (TLC)
Livello qualitativo
Stato
powder
Punto di fusione
146 °C
Solubilità
H2O: 50 mg/mg protein
Temperatura di conservazione
−20°C
Stringa SMILE
N[C@H]1CONC1=O
InChI
1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m0/s1
DYDCUQKUCUHJBH-REOHCLBHSA-N
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Azioni biochim/fisiol
Blocks sphingosine biosynthesis by inhibition of ketosphinganine synthetase. Cytotoxicity toward neuroblastoma and medulloblastoma cells mediated by suppression of ganglioside synthesis.
L-cycloserine is a potent inhibitor of serine palmitoyltransferase, the first step of sphingolipid synthesis.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Human neuroblastoma and medulloblastoma express abnormal ganglioside patterns especially GD2 and GM2 which are important for tumour growth. We tested the effects of L-cycloserine (L-CS), a potent inhibitor of synthesis of glycosphingolipids, on the growth, viability and expression of GD2
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