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C0400

Sigma-Aldrich

Carmustine

≥98% (TLC), oily liquid to amorphous solid, DNA alkylating agent

Sinonimo/i:

1,3-Bis(2-chloroethyl)-1-nitrosourea, BCNU

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About This Item

Formula empirica (notazione di Hill):
C5H9Cl2N3O2
Numero CAS:
154-93-8
Peso molecolare:
214.05
Numero CE:
205-838-2
Numero MDL:
MFCD00057706
Codice UNSPSC:
12352200
ID PubChem:
24278289
NACRES:
NA.77

Nome del prodotto

Carmustine, ≥98%

Livello qualitativo

200

Saggio

≥98%

Stato

(Oily liquid to amorphous solid)

Punto di fusione

30 °C (lit.)

Solubilità

ethanol: 19.60-20.40 mg/mL, clear, pale yellow to yellow

Ideatore

Bristol-Myers Squibb

Temperatura di conservazione

−20°C

Stringa SMILE

ClCCNC(=O)N(CCCl)N=O

InChI

1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
DLGOEMSEDOSKAD-UHFFFAOYSA-N

Informazioni sul gene

human ... GSR(2936)

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Descrizione generale

Carmustine is a mustard gas related β-chloro-nitrosourea compound, which is used in chemotherapy. It inhibits DNA replication and DNA transcription.

Applicazioni

Carmustine has been used to select transduced cells expressing MGMTP140K, a foamy virus vector. It has also been used in fluorescence-activated cell sorting (FACS) assay, to test the response of cell lines to carmustine.

Azioni biochim/fisiol

Carmustine is a DNA alkylating agent causing DNA interstrand crosslinks. Effective against glioma and other solid tumors.

Caratteristiche e vantaggi

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H300,H350,H360

Consigli di prudenza

P201 - P301 + P310 + P330

Classi di pericolo

Acute Tox. 2 Oral - Carc. 1B - Repr. 1B

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
059M4075V
13180903
128M4146V
078M4032V
018M4057V

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S-[(2-Chloroethyl)carbamoyl]glutathione (SCCG), a compound formed during the decomposition of BCNU in the presence of GSH, induces DNA damage in a human lymphoblastoid cell line. This GSH conjugate was shown by direct fast atom bombardment mass spectrometric analysis to transfer an
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