B8299

N-Butyldeoxynojirimycin

film (dried in situ), ≥98% (TLC)

• Sinonimo/i: Miglustat, NB-DNJ
• Formula empirica (notazione di Hill): C₁₀H₂₁NO₄
• Numero CAS: 72599-27-0
• Peso molecolare: 219.28
• Numero MDL: MFCD00272581
• Codice UNSPSC: 12352200
• ID PubChem: 24892070
• NACRES: NA.32

Proprietà

• product name: N-Butyldeoxynojirimycin, film (dried in situ)
• Saggio: ≥98% (TLC)
• Livello qualitativo: 200
• Forma fisica: film (dried in situ)
• Solubilità: water: 9.80-10.20 mg/mL, clear, colorless
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
• InChI: 1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1; UQRORFVVSGFNRO-UTINFBMNSA-N
• Informazioni sul gene: human ... UGCG(7357)

Descrizione

Descrizione generale

N-Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin.

Applicazioni

N-Butyldeoxynojirimycin has been used:

• in the inhibition of glycolipid synthesis in neuroblastoma cells
• in the inhibition the ceramide-specific glycosyltransferase in hepatocytes
• in the inhibition of β-glucosidase (GBA2) using fluorescence- activity assay in human embryonic kidney (HEK293) cells.

Azioni biochim/fisiol

N-Butyldeoxynojirimycin is an inhibitor of glucosyltransferase and α-glucosidases. N-Butyldeoxynojirimycin, also known as misglustat, reduces glycolipid levels by substrate reduction therapy (SRT) and is effectively used for the treatment of glycosphingolipid lysosomal storage disorder, Gaucher disease.

α-glucosidase Inhibitor

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)