T8516

Trifluoperazine dihydrochloride

≥99%, powder

• Sinonimo/i: 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride
• Formula empirica (notazione di Hill): C₂₁H₂₄F₃N₃S · 2HCl
• Numero CAS: 440-17-5
• Peso molecolare: 480.42
• Beilstein: 3820024
• Numero CE: 207-123-0
• Numero MDL: MFCD00012656
• Codice UNSPSC: 12352200
• ID PubChem: 57654709
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥99%
• Stato: powder
• Colore: white to off-white
• Punto di fusione: 243 °C (dec.) (lit.)
• Solubilità: ethanol: soluble 5 mg/mL; H₂O: soluble 50 mg/mL, clear, colorless to yellow; DMSO: soluble
• Temperatura di conservazione: −20°C
• Stringa SMILE: Cl[H].Cl[H].CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1
• InChI: 1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H; BXDAOUXDMHXPDI-UHFFFAOYSA-N
• Informazioni sul gene: human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356) , HTR2C(3358)

Descrizione

Applicazioni

Trifluoperazine dihydrochloride has been used as a calmodulin kinase antagonist in cultured Aplysia californica neurons. Trifluoperazine dihydrochloride has also been used as a PMCA inhibitor in mouse duodenal tissues to block the transcellular active calcium flux.

Trifluoperazine dihydrochloride has been used:

• to inhibit clathrin-dependent endocytosis
• as a calmodulin kinase antagonist in cultured Aplysia californica neurons
• as a plasma membrane Ca²⁺-ATPase (PMCA) inhibitor in mouse duodenal tissues to block the transcellular active calcium flux

Azioni biochim/fisiol

Phenothiazine antipsychotic; D₂ dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.

Trifluoperazine dihydrochloride is useful in treating schizophrenia, disturbed behavior, severe anxiety, nausea and vomiting.

Caratteristiche e vantaggi

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota sulla preparazione

Trifluoperazine dihydrochloride dissolves in water at 50 mg/ml, with heat as required, and yields a clear, colorless to yellow solution. It is also soluble in DMSO and ethanol (5 mg/ml).

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H319,H336,H341,H372,H410
• Consigli di prudenza: P201 - P273 - P301 + P312 + P330 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Muta. 2 - STOT RE 1 - STOT SE 3
• Organi bersaglio: Central nervous system, Eyes
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves