B7273

Bezafibrate

≥98%, solid

• Sinonimo/i: 2-[4-[2-(4-Chlorobenzamido)ethyl]phenoxy]-2-methylpropanoic acid
• Formula empirica (notazione di Hill): C₁₉H₂₀ClNO₄
• Numero CAS: 41859-67-0
• Peso molecolare: 361.82
• Numero CE: 255-567-9
• Numero MDL: MFCD00078970
• Codice UNSPSC: 12352200
• ID PubChem: 24891983
• NACRES: NA.77

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98%
• Forma fisica: solid
• Solubilità: DMF: soluble; deionized water: insoluble; methanol: soluble
• Ideatore: Roche
• Stringa SMILE: CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(O)=O
• InChI: 1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24); IIBYAHWJQTYFKB-UHFFFAOYSA-N
• Informazioni sul gene: human ... HBA2(3040) , PPARA(5465) , PPARD(5467) , PPARG(5468) ; mouse ... Ppara(19013) , Ppard(19015) , Pparg(19016)

Descrizione

Applicazioni

Bezafibrate has been used:

• a supplement in the standard diet (SD) for mice to study its effect on diabetes
• to evaluate its effect on hepatitis C virus (HCV) assembly and secretion
• to evaluate its effect on gonadal steroidogenesis and spermatogenesis of zebrafish and also used as standard for HPLC

Azioni biochim/fisiol

Bezafibrate has the ability to repress HCV assembly and secretion. It is used to treat dyslipidemia.

The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid nuclear receptor superfamily. Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.
PPARgamma agonists, including Bezafibrate, have beneficial effects in the suppression of the inflammatory response during RSV infection and therefore might have clinical efficacy in the course of severe RSV-infection.

Caratteristiche e vantaggi

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves