A9834
2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine
≥98%
Sinonimo/i:
AMT
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About This Item
Formula empirica (notazione di Hill):
C5H10N2S · HCl
Numero CAS:
Peso molecolare:
166.67
Numero MDL:
Codice UNSPSC:
12352202
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Origine biologica
synthetic (organic)
Livello qualitativo
Saggio
≥98%
Stato
powder
Solubilità
water: 25 mg/mL, clear, colorless
Temperatura di conservazione
2-8°C
Stringa SMILE
Cl[H].CC1CCN=C(N)S1
InChI
1S/C5H10N2S.ClH/c1-4-2-3-7-5(6)8-4;/h4H,2-3H2,1H3,(H2,6,7);1H
HVJCRMIQAMEJNM-UHFFFAOYSA-N
Informazioni sul gene
human ... FPGS(2356)
Categorie correlate
Azioni biochim/fisiol
As a selective type II (inducible) nitric oxide synthase (NOS) inhibitor, AMT was tested against LPS-induced inflammation in rats.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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W R Tracey et al.
Canadian journal of physiology and pharmacology, 73(5), 665-669 (1995-05-01)
Selective type II (inducible) nitric oxide synthase (NOS) inhibitors have several potential therapeutic applications, including treatment of sepsis, diabetes, and autoimmune diseases. The ability of two novel, selective inhibitors of type II NOS, S-ethylisothiourea (EIT) and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT), to inhibit
M Nakane et al.
Molecular pharmacology, 47(4), 831-834 (1995-04-01)
We have identified two novel potent and selective inhibitors of inducible nitric oxide synthase, S-ethylisothiourea and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine. Ki values of 14.7 nM for S-ethylisothiourea and 4.2 nM for 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine were obtained with partially purified preparations of inducible nitric oxide synthase.
Axelle Cooreman et al.
International journal of molecular sciences, 23(9) (2022-05-15)
Connexin43 (Cx43) hemichannels form a pathway for cellular communication between the cell and its extracellular environment. Under pathological conditions, Cx43 hemichannels release adenosine triphosphate (ATP), which triggers inflammation. Over the past two years, azithromycin, chloroquine, dexamethasone, favipiravir, hydroxychloroquine, lopinavir, remdesivir
Ju Hee Lee et al.
Archives of pharmacal research, 38(7), 1304-1311 (2015-03-07)
The aerial parts of Houttuynia cordata used for treating inflammation-related disorders contain flavonoids as major constituents. Since certain flavonoids possess anti-inflammatory activity, especially in the lung, the pharmacological activities of H. cordata and the flavonoid constituents were evaluated using in
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