A3487

Clarithromycin

96.0-102.0% (HPLC)

• Sinonimo/i: 6-O-Methylerythromycin
• Formula empirica (notazione di Hill): C₃₈H₆₉NO₁₃
• Numero CAS: 81103-11-9
• Peso molecolare: 747.95
• Numero MDL: MFCD00865140
• Codice UNSPSC: 51102829
• ID PubChem: 329770825
• NACRES: NA.85

Proprietà

• Origine biologica: synthetic
• Livello qualitativo: 200
• Saggio: 96.0-102.0% (HPLC)
• Forma fisica: powder
• Colore: white to off-white
• Spettro attività antibiotica: Gram-negative bacteria; Gram-positive bacteria
• Modalità d’azione: protein synthesis | interferes
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O[C@@H]([C@@](O)(C)[C@@H](CC)OC([C@H](C)[C@H]1O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(OC)C2)=O)[C@@H](C)C([C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]1C)=O
• InChI: 1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1; AGOYDEPGAOXOCK-KCBOHYOISA-N

Descrizione

Applicazioni

Clarithromycin has been used to study its effect on the potassium channel KCNJ5^WT.

Azioni biochim/fisiol

Clarithromycin is stable in gastric acid.

Clarithromycin possess bactericidal activity including anti-mycobacterial activity against Mycobacterium leprae, and M.avium complex.

Clarithromycin is a macrolide antibiotic that interferes with bacterial protein synthesis. Clarithromycin is an acid-stable version of erythromycin and is particularly effective against Gram-negative bacteria. It has a short half-life, however its metabolite, 14-hydroxy clarithromycin is nearly twice as active as clarithromycin against certain bacteria.

Confezionamento

100mg

Nota sulla preparazione

Practically insoluble in water, soluble in acetone and methylene chloride, slightly soluble in methanol.

Altre note

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P301 + P312 + P330
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable