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A3234

Sigma-Aldrich

Apolipoprotein E4 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE and HPLC), lyophilized powder

Sinonimo/i:

ApoE4

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About This Item

Numero MDL:
MFCD00285515
Codice UNSPSC:
12352202
NACRES:
NA.32

Ricombinante

expressed in E. coli

Livello qualitativo

100

Saggio

≥90% (SDS-PAGE and HPLC)

Forma fisica

lyophilized powder

N° accesso UniProt

P02649

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... APOE(348)

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Descrizione generale

Apolipoprotein E (ApoE) is present in the brain and is mainly produced by astrocytes. It is a 299 amino acid glycoprotein of 34kDa. It is present in all classes of lipoproteins except LDL (low-density lipoprotein). APOE gene has three alleles, such as APOE ε3, APOE ε4 and APOE ε2. It is located on human chromosome 19q13.

Azioni biochim/fisiol

ApoE4 (apolipoprotein E4) is associated with AD (Alzheimer′s disease).
Apolipoprotein E4 is a member of the apolipoprotein E family of plasma lipoproteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. ApoE4 regulates plasma lipid levels by increasing the degradation of particles rich in triglycerides and cholesterol. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, regulate the activity of enzymes involved in lipid metabolism and bind amyloid-β protein, the major component of plaques in Alzheimer′s disease, which it delivers to the microglia, the major scavenger cells of brain. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer′s disease. ApoE exists in three major isoforms: E2, E3, and E4, which differ from one another by a single amino-acid substitution. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues.

Stato fisico

Lyophillized from a 0.2 μm filtered solution in 20 mM sodium phosphate, pH 7.8.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models
Huang Y
Biochemical Society Transactions, 120(4), 702-736 (2011)
Twenty years of the Alzheimer?s disease amyloid hypothesis: a genetic perspective
Tanzi R E and Bertram L
Cell, 120(4), 545-555 (2005)
Lipids and disorders of lipoprotein metabolism
Clinical Biochemistry, 120(4), 702-736 (2014)
Traumatic Brain Injury
Neurobiology of Brain Disorders, 120(4), 219-235 (2015)

Articoli

Alzheimer's Disease

Alzheimer's disease (AD) is the most common cause of dementia in the elderly and is characterized by gradual loss of cognitive functions.

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