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A255

Sigma-Aldrich

A-77636 hydrochloride hydrate

≥98% (HPLC), solid

Sinonimo/i:

(−)-(1R,3S)-3-Adamantyl-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride hydrate

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About This Item

Formula empirica (notazione di Hill):
C20H27NO3 · HCl · xH2O
Numero CAS:
145307-34-2
Peso molecolare:
365.89 (anhydrous basis)
Codice UNSPSC:
12352200
ID PubChem:
24277883
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

solid

Condizioni di stoccaggio

desiccated
protect from light

Colore

white to off-white

Solubilità

H2O: >10 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

O.Cl.NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)C34CC5CC(CC(C5)C3)C4

InChI

1S/C20H27NO3.ClH.H2O/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20;;/h1-2,11-13,17-18,22-23H,3-10,21H2;1H;1H2/t11?,12?,13?,17-,18-,20?;;/m0../s1
KNACNUUSUYTFDY-LIWDBWMRSA-N

Informazioni sul gene

human ... DRD1(1812)

Azioni biochim/fisiol

Potent, orally active D1 dopamine receptor agonist.

Caratteristiche e vantaggi

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Avvertenza

Hygroscopic, photosensitive, and oxygen-sensitive. Solutions should be freshly prepared.

Note legali

Manufactured and sold under exclusive license from Abbott Laboratories.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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L A Smith et al.
Journal of neural transmission (Vienna, Austria : 1996), 109(2), 123-140 (2002-06-22)
The potent and long acting D-1 receptor agonist, A-77636 reverses motor deficits in MPTP treated common marmosets following subcutaneous or oral administration. We now explore the effects of acute versus repeated administration of A-77636 and the relative roles of D-1
J Grider et al.
European journal of pharmacology, 342(2-3), 281-284 (1998-04-21)
The aim of the present study was to determine whether dopamine affects NaCl reabsorption in the medullary thick ascending limb of the loop of Henle. Basolateral dopamine (10(-6) M) significantly inhibited Cl- reabsorption in the in vitro microperfused rat medullary
P J Blanchet et al.
European journal of pharmacology, 309(1), 13-20 (1996-08-01)
The motor effects of dopamine D1 receptor activation and the optimal way to stimulate these receptors were studied in a primate model of parkinsonism induced by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), using 2 selective full dopamine D1 receptor agonists: A-77636 ([1
E Acquas et al.
The Journal of pharmacology and experimental therapeutics, 281(1), 360-368 (1997-04-01)
The role of dopamine (DA) D1 receptors in the regulation of acetylcholine (ACh) release in the striatum was studied using in vivo microdialysis in freely moving rats. Systemic administration of the full D1 DA receptor agonist A-77636 (4 micromol/kg) increased
D Wirtshafter et al.
Brain research, 750(1-2), 245-250 (1997-03-07)
We have previously shown that systemic administration of non-selective dopamine agonists results in a pronounced expression of the proto-oncoprotein Fos within the lateral habenula. In the current study we examined the effects of selective D1 and D2 dopamine receptor agonists
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