A1824

N-Acetyl-5-hydroxytryptamine

≥99% (HPLC), powder, antioxidant

• Sinonimo/i: N-Acetylserotonin, Normelatonin
• Formula empirica (notazione di Hill): C₁₂H₁₄N₂O₂
• Numero CAS: 1210-83-9
• Peso molecolare: 218.25
• Numero CE: 214-916-5
• Numero MDL: MFCD00005656
• Codice UNSPSC: 12352209
• ID PubChem: 24278209
• NACRES: NA.32

Proprietà

• Nome del prodotto: N-Acetyl-5-hydroxytryptamine, ≥99% (HPLC), powder
• Livello qualitativo: 200
• Saggio: ≥99% (HPLC)
• Stato: powder
• Colore: white to faint yellow
• Punto di fusione: 120-122 °C (lit.)
• Solubilità: ethanol: 50 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CC(=O)NCCc1c[nH]c2ccc(O)cc12
• InChI: 1S/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15); MVAWJSIDNICKHF-UHFFFAOYSA-N
• Informazioni sul gene: human ... MTNR1A(4543) , MTNR1B(4544)

Descrizione

Descrizione generale

N-Acetylserotonin (NAS)/normelatonin acts as a precursor of melatonin in the tryptophan metabolic pathway.

Applicazioni

N-Acetyl-5-hydroxytryptamine has been used to treat neuron cells and to analyze its effects on Krüppel-like factor 15 (KLF15) expression.

Azioni biochim/fisiol

N-acetyl-serotonin (NAS/normelatonin) can act as a shelter to neurons due to its protecting ability against oxidative challenges. It can also repress the actions of the transcription factor NF-kappaB. NAS possesses antioxidant and antiaging actions. It has protective action against β-amyloid induced neurotoxicity. It helps to maintain the optimal fluidity of the biological membranes.

Immediate precursor of melatonin. It is formed from serotonin and acetyl-CoA in a reaction catalyzed by serotonin N-acetyl transferase, the rate-limiting enzyme in melatonin biosynthesis. This indoleamine is a weak agonist at melatonin receptors, and has moderate effects on G-protein stimulation and inhibition of cAMP accumulation.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)