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86614

Sigma-Aldrich

Tetraethylammonium chloride

BioUltra, for molecular biology, ≥99.0% (AT)

Sinonimo/i:

Etamon chloride, TEAC, TEA chloride

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About This Item

Formula condensata:
(C2H5)4N(Cl)
Numero CAS:
Peso molecolare:
165.70
Beilstein:
3563247
Numero CE:
Numero MDL:
Codice UNSPSC:
12352107
ID PubChem:
NACRES:
NA.26

Grado

Molecular Biology
for molecular biology

Livello qualitativo

Nome Commerciale

BioUltra

Saggio

≥99.0% (AT)

Stato

powder

PM

165.70 g/mol

tecniche

gas chromatography (GC): suitable

Impurezze

DNases, none detected
RNases, none detected
insoluble matter, passes filter test
phosphatases, none detected
proteases, none detected

Solubilità

H2O: 1 M at 20 °C, clear, colorless

Anioni in tracce

bromide (Br-): ≤500 mg/kg
sulfate (SO42-): ≤50 mg/kg

Cationi in tracce

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

1 M in H2O

Assorbanza UV

λ: 260 nm Amax: 0.03
λ: 280 nm Amax: 0.03

Stringa SMILE

[Cl-].CC[N+](CC)(CC)CC

InChI

1S/C8H20N.ClH/c1-5-9(6-2,7-3)8-4;/h5-8H2,1-4H3;1H/q+1;/p-1
YMBCJWGVCUEGHA-UHFFFAOYSA-M

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Descrizione generale

Tetraethylammonium (TEA), a simple quaternary ammonium compound, is commonly used to block potassium channels. It can physically enter the pore and block the channel. Additionally, TEA either imitates or antagonizes the actions of choline and acetylcholine, two other quaternary ammonium ions.

Applicazioni

Tetraethylammonium chloride has been used:

  • as a pharmacological agent in electrophysiology to study its pharmacological effects on Cnidarians
  • as a component in refolding buffer for protein refolding
  • to puff onto isolated patches to block voltage-gated K+ (Kv3) channels and post-hoc evaluation

Caratteristiche e vantaggi

  • Assay: ≥99.0% (AT), BioUltra, for molecular biology
  • Suitable for gas chromatography (GC)

Altre note

TEACl method of DNA-DNA hybridization

Pittogrammi

Exclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

201.2 °F - closed cup

Punto d’infiammabilità (°C)

94 °C - closed cup

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves


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A. Caccone et al.
NATO ASI Ser., Ser H, 57, 385-385 (1991)
Timothy S Balmer et al.
eLife, 10 (2021-02-23)
Synapses of glutamatergic mossy fibers (MFs) onto cerebellar unipolar brush cells (UBCs) generate slow excitatory (ON) or inhibitory (OFF) postsynaptic responses dependent on the complement of glutamate receptors expressed on the UBC's large dendritic brush. Using mouse brain slice recording
Lorena Pochini et al.
International immunopharmacology, 29(1), 21-26 (2015-05-06)
OCTN1 was immuno-detected in the cervical cancer cell HeLa, in which the complete pattern of acetylcholine metabolizing enzymes is expressed. Comparison of immuno-staining intensity of HeLa OCTN1 with the purified recombinant human OCTN1 allowed measuring the specific OCTN1 concentration in
Fernanda S Gravina et al.
PloS one, 9(10), e111307-e111307 (2014-10-23)
The pacemaker mechanisms activating phasic contractions of vaginal and cervical smooth muscle remain poorly understood. Here, we investigate properties of pacemaking in vaginal and cervical tissues by determining whether: 1) functional pacemaking is dependent on the phase of the estrus
Samuel J Goodchild et al.
The Journal of general physiology, 140(5), 495-511 (2012-10-17)
The open state of voltage-gated potassium (Kv) channels is associated with an increased stability relative to the pre-open closed states and is reflected by a slowing of OFF gating currents after channel opening. The basis for this stabilization is usually

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