59983

Josamycin

≥90% (HPLC)

• Sinonimo/i: Leucomycin A3
• Formula empirica (notazione di Hill): C₄₂H₆₉NO₁₅
• Numero CAS: 16846-24-5
• Peso molecolare: 827.99
• Numero CE: 240-871-6
• Numero MDL: MFCD00211043
• Codice UNSPSC: 51102829
• ID PubChem: 57651709
• NACRES: NA.85

Proprietà

• Livello qualitativo: 200
• Saggio: ≥90% (HPLC)
• Stato: powder
• Colore: white to slightly yellow
• Spettro attività antibiotica: Gram-positive bacteria
• Modalità d’azione: protein synthesis | interferes
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CO[C@H]1[C@@H](CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)OC(C)=O
• InChI: 1S/C42H69NO15/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1; XJSFLOJWULLJQS-NGVXBBESSA-N

Descrizione

Descrizione generale

Chemical structure: macrolide

Applicazioni

Josamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics, immunomodulatory effects, the suppression of matrix metalloproteinase production as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit.

Azioni biochim/fisiol

Josamycin inhibits bacterial protein biosynthesis by inhibiting peptidyltransferase and ribosomal translocation, and depleting the intracellular pools of aminoacyl-tRNAs available for protein synthesis by drop-off and incomplete peptidyl-tRNA hydrolase activity. It slows down formation of the first peptide bond of a nascent peptide in an amino acid-dependent way and inhibits formation of the second or third peptide bond.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Altre note

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)