56250

trans-4-Hydroxy-L-proline

≥99.0% (NT), BioXtra

• Sinonimo/i: (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, Hyp
• Formula empirica (notazione di Hill): C₅H₉NO₃
• Numero CAS: 51-35-4
• Peso molecolare: 131.13
• Beilstein: 81441
• Numero CE: 200-091-9
• Numero MDL: MFCD00064320
• Codice UNSPSC: 12352209
• ID PubChem: 57651574
• NACRES: NA.26

Proprietà

• product name: trans-4-Hydroxy-L-proline, BioXtra, ≥99.0% (NT)
• Nome Commerciale: BioXtra
• Livello qualitativo: 100
• Saggio: ≥99.0% (NT)
• Forma fisica: solid
• Attività ottica: [α]20/D −76.0±1.5°, c = 5% in H₂O
• Impurezze: ≤0.3% foreign amino acids
• Residuo alla calcinazione: ≤0.1% (as SO₄)
• Perdita: ≤0.1% loss on drying, 110 °C
• Colore: colorless to white
• Punto di fusione: 273 °C (dec.) (lit.)
• Anioni in tracce: chloride (Cl^-): ≤100 mg/kg; sulfate (SO₄^2-): ≤100 mg/kg
• Cationi in tracce: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; NH₄⁺: ≤100 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• applicazioni: peptide synthesis
• Stringa SMILE: O[C@H]1CN[C@@H](C1)C(O)=O
• InChI: 1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1; PMMYEEVYMWASQN-DMTCNVIQSA-N

Descrizione

Azioni biochim/fisiol

Trans-4-Hydroxy-L-proline is used as a starting material in the synthesis of (-)-secrinine; the synthesis of prolinol-based nucleotide analogues with N-phosphonomethyl moiety attached to the nitrogen atom of prolinol ring and in asymmetric synthesis of the ABC-ring system of the antitumor antibiotic MPC1001.

Trans-4-Hydroxy-L-proline is used in the organic synthesis of depsilairdin analogues, noncompetitive peptidomimetic inhibitors of multidrug resistance P-glycoprotein and 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analogues.

Altre note

Natural constituent of animal structural proteins such as collagen and elastin.

Enzymes and intermediates of hydroxyproline degradation

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)