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Key Documents

52423

Sigma-Aldrich

Dextran sulfate sodium salt from Leuconostoc spp.

low sulfate content, Mr ~40,000

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About This Item

Numero CAS:
9011-18-1
Numero MDL:
MFCD00081551
Codice UNSPSC:
12352201
NACRES:
NA.25

Origine biologica

(Leuconostoc spp)

Livello qualitativo

100

Forma fisica

powder

Qualità

low sulfate content

PM

Mr ~40,000

Composizione

Sulfur Content, 8-13%

Perdita

≤10% loss on drying

Colore

white to off-white

Intervallo di pH utile

6.0-8 (10 g/L)

Solubilità

H2O: 100 mg/mL, clear, colorless to faintly greenish-yellow

Temperatura di conservazione

room temp

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Descrizione generale

Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.

Applicazioni

Dextran sulfate increases binding of epithelial cells and lymphocytes to extracellular matrix proteins including fibronectin and laminin. In addition, dextran sulfate altered expreβion of cell surface receptors integrins.
Dextran sulfate is routinely used for the selective precipitation of lipoproteins, probe hybridization membrane-immobilized DNA, the release of DNA from DNA-histone complexes, and the inhibition of RNA binding to ribosomes.

Nota sulla preparazione

Sigma dextrans are derived from Leuconostoc mesenteroides.

Altre note

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Azossimetano 13.4 M, ≥98%

Sigma-Aldrich

A5486

Azossimetano

Dextran Sulfate, Sodium Salt, Molecular Biology Grade Used to accelerate hybridization of DNA probes to immobilized nucleic acids.

Millipore

265152-M

Dextran Sulfate, Sodium Salt, Molecular Biology Grade

Solfato di destrano

SAFC

RES2029D-A7

Solfato di destrano

Solfato di destrano Mw 7,000-20,000

Sigma-Aldrich

51227

Solfato di destrano

Destrano Mr ~40,000

Sigma-Aldrich

31389

Destrano

J Ni et al.
Gut, 39(2), 234-241 (1996-08-01)
The effects of dextran sulphate sodium (DSS) on mouse intestinal epithelial cells and intraepithelial lymphocytes were analysed to investigate the mechanism by which DSS induces colitis and tumours in mice. Cytotoxicity of DSS towards intestinal epithelial cells and intestinal intraepithelial
Jiang-Hua Liu et al.
Disease models & mechanisms, 13(11) (2020-10-10)
Improving revascularization is one of the major measures in fracture treatment. Moderate local inflammation triggers angiogenesis, whereas systemic inflammation hampers angiogenesis. Previous studies showed that Akkermansia muciniphila, a gut probiotic, ameliorates systemic inflammation by tightening the intestinal barrier. In this
Aaron H Rose et al.
Inflammatory bowel diseases, 21(9), 2005-2015 (2015-06-16)
An important role has emerged for calpain enzymes in regulating inflammation with one isoform, calpain-2, particularly important for macrophage activation. The goal of this study was to determine the therapeutic potential of a synthetic calpain-2 inhibitor, zLLY-CH2F, for colitis and

Articoli

FITC-labelled polysaccharides

Additional information about FITC-labelled polysaccarides including FITC-Dextran, FITC-DEAE-dextran (FDD), FITC-carboxymethyl-dextran (FCM-Dextran). This page discusses the impact of weight-average molecular weight on the respective molecule dimensions and other physical properties

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