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Documenti fondamentali

272M-1

Sigma-Aldrich

INI-1 (MRQ-27) Mouse Monoclonal Antibody

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

100
500

Coniugato

unconjugated

Forma dell’anticorpo

culture supernatant

Tipo di anticorpo

primary antibodies

Clone

MRQ-27, monoclonal

Descrizione

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forma fisica

buffered aqueous solution

Reattività contro le specie

human

Confezionamento

vial of 0.1 mL concentrate (272M-14)
vial of 0.5 mL concentrate (272M-15)
bottle of 1.0 mL predilute (272M-17)
vial of 1.0 mL concentrate (272M-16)
bottle of 7.0 mL predilute (272M-18)

Produttore/marchio commerciale

Cell Marque™

tecniche

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Controllo

brain, endothelial cells

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

Visualizzazione

nuclear

Informazioni sul gene

human ... SMARCB1(6598)

Categorie correlate

Descrizione generale

INI-1, also known as SMARCB1, is one of the core subunit proteins of the ATP-dependent SWI/SNF chromatin remodeling complex. It is involved in chromatin remodeling and transcriptional regulation and functions as a tumor suppressor. Nuclear INI-1 expression is seen in virtually all normal human tissues and most malignancies but the INI-1 gene is often mutated or deleted in malignant rhabdoid tumors (MRT), including those arising in the central nervous system, leading to a lack of INI-1 expression.

Qualità


IVD
IVD
IVD
RUO

Linkage

INI-1 Positive Control Slides, Product No. 272S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota sulla preparazione

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Altre note

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Note legali

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificati d'analisi (COA)

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Christine Haberler et al.
The American journal of surgical pathology, 30(11), 1462-1468 (2006-10-26)
Immunohistochemical lack of nuclear INI1 protein expression has been recently described as characteristic finding in atypical teratoid/rhabdoid tumors (AT/RTs), and has been suggested as useful marker to distinguish AT/RTs from other malignant pediatric central nervous system (CNS) tumors. In this
F Bourdeaut et al.
The Journal of pathology, 211(3), 323-330 (2006-12-08)
Rhabdoid tumours (RTs) are rare but highly aggressive tumours of childhood. Their rarity and their miscellaneous locations make the diagnosis particularly challenging for pathologists. Central nervous system and peripheral RTs have been associated with biallelic inactivation of the hSNF5/INI1/SMARCB1 (hSNF5/INI1)
D J Fowler et al.
Fetal and pediatric pathology, 25(3), 159-168 (2006-10-25)
Primary extrarenal rhabdoid tumors (RT) are now recognized as a specific entity in pediatric oncological pathology practice. We present an unusual case of a small cell myxoid variant of a thoracic RT in an infant and highlight the importance of

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