379R-1

Carbonic Anhydrase IX (CA IX) (EP161) Rabbit Monoclonal Primary Antibody

• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100; 500
• Coniugato: unconjugated
• Forma dell’anticorpo: culture supernatant
• Tipo di anticorpo: primary antibodies
• Clone: EP161, monoclonal
• Descrizione: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: human
• Confezionamento: bottle of 1.0 mL predilute (379R-17); bottle of 7.0 mL predilute (379R-18); vial of 0.1 mL concentrate (379R-14); vial of 0.5 mL concentrate (379R-15); vial of 1.0 mL concentrate (379R-16)
• Produttore/marchio commerciale: Cell Marque^™
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
• Isotipo: IgG
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• Informazioni sul gene: human ... CA9(768)

Descrizione

Descrizione generale

Carbonic anhydrases are a family of zinc containing metalloproteins that catalyze the reversible hydration of CO₂. Among these, carbonic anhydrase IX (CA IX) is anchored to the cell membrane and is expressed in the human gastrointestinal tract, chiefly in the stomach and gall bladder¹. It is interesting to note that CA IX is overexpressed in epithelial malignancies of the uterus, cervix, lung, breast, and kidney; none of the associated normal tissues express this isozyme.^1-4 CA IX is said to maintain the extracellular acidic pH, thus promoting cell growth in these tumors.⁵ Preliminary data suggest consistent immunoreactivity for anti-CA IX in clear cell renal cell carcinoma (RCC) with demonstrated sensitivity of 85% to 100%.² Anti-CA IX, together with antibodies against PAX-2, Ksp-cadherin, and CD117, contributes to a robust panel that can be used to help make this distinction. Strong diffuse-to-multifocal immunostaining for anti-CA IX is observed in the large majority of urothelial carcinomas as opposed to the extremely weak and focal immunoreactivity seen in collecting duct carcinoma (CDC). Anti-CA IX can thus aid in distinguishing between urothelial carcinoma and CDC.⁶

Qualità

IVD

IVD

IVD

RUO

Linkage

Carbonic Anhydrase IX (CA IX) Positive Control Slides, Product No. 379S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota sulla preparazione

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Altre note

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Note legali

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable