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Key Documents

395R-1

Sigma-Aldrich

c-Myc (EP121) Rabbit Monoclonal Primary Antibody

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100
500

Coniugato

unconjugated

Forma dell’anticorpo

culture supernatant

Tipo di anticorpo

primary antibodies

Clone

EP121, monoclonal

Descrizione

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forma fisica

buffered aqueous solution

Reattività contro le specie

human

Confezionamento

vial of 0.1 mL concentrate (395R-14)
vial of 0.5 mL concentrate (395R-15)
bottle of 1.0 mL predilute (395R-17)
vial of 1.0 mL concentrate (395R-16)
bottle of 7.0 mL predilute (395R-18)

Produttore/marchio commerciale

Cell Marque

tecniche

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

Isotipo

IgG

Controllo

Burkitt lymphoma, prostate carcinoma

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

Visualizzazione

nuclear

Informazioni sul gene

human ... MYC(4609)

Descrizione generale

c-Myc is a transcription factor that drives the growth and proliferation of cells. c-Myc isamplified in many different solid and hematopoietic tumors. Immunohistochemistry forc-Myc protein is used to identify the presence of a c-Myc translocation in various tumors,most frequently to aid in the diagnosis of Burkitt lymphoma.

Qualità


IVD

IVD

IVD

RUO

Linkage

c-Myc Positive Control Slides, Product No. 395S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota sulla preparazione

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Altre note

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Note legali

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificati d'analisi (COA)

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Christopher W Toon et al.
PloS one, 9(2), e87456-e87456 (2014-02-08)
MYC over-expression as determined by molecular means has been reported as a favorable prognostic biomarker in colorectal carcinoma (CRC). However MYC expression analysis is not available in the routine clinical setting. We investigated whether immunohistochemistry (IHC) for the myc protein
Bora Gurel et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21(9), 1156-1167 (2008-06-24)
The MYC onco-protein is a transcription factor that regulates cell proliferation, metabolism, protein synthesis, mitochondrial function and stem cell renewal. A region on chromosome 8q24 encompassing the MYC locus is amplified in prostate cancer, but this occurs mostly in advanced
Tina Marie Green et al.
The American journal of surgical pathology, 36(4), 612-619 (2012-02-09)
Determining the presence of MYC gene rearrangements is becoming an increasingly important part of the diagnostic workup in aggressive lymphoma. Cytogenetic MYC alterations aid in differentiating diffuse large B-cell lymphoma (DLBCL) from Burkitt lymphoma. In addition, MYC aberrations are associated
Sietse M Aukema et al.
Blood, 117(8), 2319-2331 (2010-12-02)
In many B-cell lymphomas, chromosomal translocations are biologic and diagnostic hallmarks of disease. An intriguing subset is formed by the so-called double- hit (DH) lymphomas that are defined by a chromosomal breakpoint affecting the MYC/8q24 locus in combination with another

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