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Y0001532

Norethisterone acetate for system suitability

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

19-Norethindrone acetate, 17α-Ethynyl-17β-hydroxy-19-nor-4-androsten-3-one 17-acetate, 17α-Ethynyl-19-nortestosterone 17β-acetate, 17-Hydroxy-19-nor-17α-4-pregnen-20-yn-3-one acetate, 19-Norethisterone 17-acetate

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About This Item

Formula empirica (notazione di Hill):
C22H28O3
Numero CAS:
51-98-9
Peso molecolare:
340.46
Numero MDL:
MFCD00271615
Codice UNSPSC:
41116107
ID PubChem:
329831477
NACRES:
NA.24

Grado

pharmaceutical primary standard

Famiglia di API

norethisterone

Produttore/marchio commerciale

EDQM

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(=O)O[C@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C)C#C

InChI

1S/C22H28O3/c1-4-22(25-14(2)23)12-10-20-19-7-5-15-13-16(24)6-8-17(15)18(19)9-11-21(20,22)3/h1,13,17-20H,5-12H2,2-3H3/t17-,18+,19+,20-,21-,22-/m0/s1
IMONTRJLAWHYGT-ZCPXKWAGSA-N

Informazioni sul gene

human ... PGR(5241)

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Categorie correlate

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Norethisterone acetate for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Pittogrammi

Health hazardEnvironment
GHS08,GHS09

Avvertenze

Danger

Indicazioni di pericolo

H351,H360FD,H362,H410

Classi di pericolo

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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A comparative study of the androgenic properties of progesterone and the progestins, medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A).
Africander D J, et al.
The Journal of Steroid Biochemistry and Molecular Biology, 143, 404-415 (2014)
F Pommier et al.
Journal of chromatography. A, 750(1-2), 75-81 (1996-10-25)
An analytical method for the determination of norethisterone acetate (NETA) in human plasma by capillary gas chromatography-mass-selective detection (GC-MS), with testosterone acetate as internal standard, was developed and validated. After addition of the internal standard, the compounds were extracted from
Bente Juel Riis et al.
American journal of obstetrics and gynecology, 187(4), 1101-1116 (2002-10-22)
This article is focused on the use of norethisterone acetate as progestogen in hormone replacement therapy. Emphasis is made on the fact that the primary reason for adding a progestogen to hormone replacement therapy is to protect the endometrium against
Norethisterone and norethisterone acetate.
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 21, 441-460 (1979-12-01)
Elizabeth E Sweeney et al.
Cancer research, 74(23), 7060-7068 (2014-10-12)
Hormone replacement therapy (HRT) is widely used to manage menopausal symptoms in women and can be comprised of an estrogen alone or an estrogen combined with a progestin. The Women's Health Initiative demonstrated in their randomized trials that estrogen alone
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