Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

SMB00938

Sigma-Aldrich

Dimethyl-L-arginine

≥95% (HPLC)

Sinonimo/i:

Dimethyl-L-arginine, (S)-2-Amino-5-(3,3-dimethylguanidino)pentanoic acid, Asymmetric dimethylarginine

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali


About This Item

Formula empirica (notazione di Hill):
C8H18N4O2
Numero CAS:
Peso molecolare:
202.25
Codice UNSPSC:
12352209
NACRES:
NA.26

Livello qualitativo

Saggio

≥95% (HPLC)

Forma fisica

powder

Colore

off-white

Temperatura di conservazione

room temp

InChI

1S/C8H18N4O2/c1-12(2)8(10)11-5-3-4-6(9)7(13)14/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14)/t6-/m0/s1
YDGMGEXADBMOMJ-LURJTMIESA-N

Descrizione generale

Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally-essential amino acid. ADMA interferes with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. Asymmetric dimethylarginine is created in protein methylation, a common mechanism of post-translational protein modification. This reaction is catalyzed by an enzyme set called S-adenosylmethionine protein N-methyltransferases (protein methylases I and II). The methyl groups transferred to create ADMA are derived from the methyl group donor S-adenosylmethionine, an intermediate in the metabolism of homocysteine. (Homocysteine is an important blood chemical, because it is also a marker of cardiovascular disease). After synthesis, ADMA migrates into the extracellular space and then into blood plasma.
Asymmetric dimethylarginine (ADMA) is a non-proteinogenic L-alpha-amino acid, that belongs to the guanidines and serves as a derivative of L-arginine. This dimethylarginine functions as an endogenous inhibitor of nitric oxide synthase (NOS) and acts as a biomarker for endothelial dysfunction in various pathological states.

Applicazioni

Asymmetric dimethylarginine is a versatile compound that finds application in biochemical and metabolomics research.

Caratteristiche e vantaggi

  • Ideal for biochemical and metabolomics studies
  • High purity product for research applications

Altre note

For additional information on our range of Biochemicals, please complete this form.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.