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Key Documents

PHR1798

Supelco

Levamisole Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Sinonimo/i:

(−)-Tetramisole hydrochloride, (S)-(−)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride, L(−)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride, Levamisole hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C11H12N2S · HCl
Numero CAS:
Peso molecolare:
240.75
Beilstein:
4358988
Numero CE:
Numero MDL:
Codice UNSPSC:
41116107
NACRES:
NA.24

Grado

certified reference material
pharmaceutical secondary standard

Livello qualitativo

agenzia

traceable to BP 212
traceable to Ph. Eur. L0380000
traceable to USP 1359302

Famiglia di API

levamisole

CdA

current certificate can be downloaded

Confezionamento

pkg of 250 mg

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

228-230 °C

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-30°C

Stringa SMILE

Cl.C1CN2C[C@@H](N=C2S1)c3ccccc3

InChI

1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1
LAZPBGZRMVRFKY-HNCPQSOCSA-N

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Descrizione generale

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Applicazioni

Levamisole Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by potentiometric sensing, spectrometric and atomic absorption spectroscopy methods.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Azioni biochim/fisiol

Shows both immunostimulant and immunosuppressant effects, depending on several controllable factors. Very effective in treatment of ascariasis (hookworm infestation). Useful in chemotherapy of colorectal cancers, possibly due to its stimulation of IL-1 production and direct activation of macrophages.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAC3172 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Prodotti consigliati

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pittogrammi

Skull and crossbones

Avvertenze

Danger

Indicazioni di pericolo

Consigli di prudenza

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Certificati d'analisi (COA)

Lot/Batch Number

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Potentiometric sensing of levamisole hydrochloride based on molecularly imprinted polymer
Sadeghi S, et al.
Sensors and Actuators B, Chemical, 122(1), 158-164 (2007)
Indirect determination of levamisole by AAS and precipitation in a continuous-flow assembly
Ortiz SL, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 48(1), 112-117 (1993)
Jote T Bulcha et al.
Cell reports, 26(2), 460-468 (2019-01-10)
Biological systems must possess mechanisms that prevent inappropriate responses to spurious environmental inputs. Caenorhabditis elegans has two breakdown pathways for the short-chain fatty acid propionate: a canonical, vitamin B12-dependent pathway and a propionate shunt that is used when vitamin B12
Sreeparna Pradhan et al.
Current biology : CB, 29(17), 2867-2879 (2019-08-20)
Foraging strategies should be tuned to the expected distribution of resources in the environment. Tuning can occur over generations and lead to genetic differences in innate foraging behavior or over shorter timescales within an individual's lifespan. Both genetically encoded and
S Khalil et al.
Journal of pharmaceutical and biomedical analysis, 22(2), 235-240 (2000-03-17)
A new simple, accurate, precise and sensitive indirect method for the determination of pindolol HCl (1), propranolol HCl (2) and levamisole HCl (3) using atomic absorption spectrometry has been developed. The method is based on precipitation of the ion-associates formed

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