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Key Documents

PHR1045

Supelco

Dietilenglicole

Pharmaceutical Secondary Standard; Certified Reference Material

Sinonimo/i:

2,2′-ossidietanolo, 2-idrossietil etere, Bis(2-idrossietil) etere, Diglicole

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About This Item

Formula condensata:
(HOCH2CH2)2O
Numero CAS:
Peso molecolare:
106.12
Beilstein:
969209
Numero CE:
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
NACRES:
NA.24

Grado

certified reference material
pharmaceutical secondary standard

Livello qualitativo

agenzia

traceable to Ph. Eur. Y0000217
traceable to USP 1193265

Densità del vapore

2.14 (vs air)

Tensione di vapore

0.01 mmHg ( 20 °C)

Famiglia di API

diethylene glycol

CdA

current certificate can be downloaded

Temp. autoaccensione

442 °F

Limite di esplosione

2-12.3 %

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Indice di rifrazione

n20/D 1.447 (lit.)

P. eboll.

245 °C (lit.)

Punto di fusione

−10 °C (lit.)

Densità

1.118 g/mL at 25 °C (lit.)

applicazioni

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-30°C

Stringa SMILE

OCCOCCO

InChI

1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2
MTHSVFCYNBDYFN-UHFFFAOYSA-N

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Descrizione generale

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Diethylene glycol is a a four carbon dimer of ethylene glycol and finds applications as antifreeze, solvent, humectant, hydraulic fluid and brake fluid. It is a potential neuro- and nephrotoxin for humans. It may also be utilized in moisturizers, lubricants, emulsification agents, additives and solvents.

Applicazioni

Diethylene glycol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC).
Diethylene glycol may be used as a standard in the determination of diethylene glycol present in serum samples using gas chromatography (GC). It may also be used as a reference standard in validating the composition of diethylene glycol in propolis syrup consumed by intoxicated victims using nuclear magnetic resonance studies (NMR) and gas chromatography coupled with flame ionization detector (GC-FID).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAC0277 in the slot below. This is an example certificate only and may not be the lot that you receive.

Prodotti consigliati

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Applicazioni

N° Catalogo
Descrizione
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Prodotti correlati

Pittogrammi

Exclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

280.4 °F - closed cup

Punto d’infiammabilità (°C)

138 °C - closed cup


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Certificati d'analisi (COA)

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Identification and quantification of diethylene glycol in pharmaceuticals implicated in poisoning epidemics: an historical laboratory perspective
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Journal of Analytical Toxicology, 31(6), 295-303 (2007)
Clinical parameters, postmortem analysis and estimation of lethal dose in victims of a massive intoxication with diethylene glycol
Ferrari.AL and Giannuzzi L
Forensic Science International, 153, 45-51 (2005)
Gas-chromatographic determination of ethylene glycol in serum
Porter H.W and Auansakul aA
Clinical Chemistry, 28, 75-78 (1982)
Tao Zhou et al.
Journal of separation science, 30(16), 2620-2627 (2007-09-21)
A simple and reliable HPLC method was developed for the simultaneous quantitative analysis of diethylene glycol (DEG) and propylene glycol (PG) in pharmaceutical products by precolumn derivatization. The derivatization reagent p-toluenesulfonyl isocyanate (TSIC, 10 microL, 20% in ACN v/v) was
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Protocolli

99%; Glycerol, ≥99.5%; Tetraethylene glycol, 99%

Chromatograms

suitable for GC

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