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Key Documents

PHR1034

Supelco

Lidocaine

Pharmaceutical Secondary Standard; Certified Reference Material

Sinonimo/i:

2-Diethylamino-N-(2,6-dimethylphenyl)acetamide, Lignocaine, Xylocaine

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About This Item

Formula empirica (notazione di Hill):
C14H22N2O
Numero CAS:
Peso molecolare:
234.34
Numero CE:
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
NACRES:
NA.24

Grado

certified reference material
pharmaceutical secondary standard

Livello qualitativo

agenzia

traceable to BP 727
traceable to Ph. Eur. L0595000
traceable to USP 1366002

Famiglia di API

lidocaine

CdA

current certificate can be downloaded

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-30°C

Stringa SMILE

CCN(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
NNJVILVZKWQKPM-UHFFFAOYSA-N

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Descrizione generale

Lidocaine is a drug, which serves as a potential candidate in the treatment of cardiac arrhythmias.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Lidocaine is a local anesthetic drug that can exhibit pronounced antiarrhythmic and anticonvulsant effects. It is known as a central nervous system depressant and shows sedative, analgesic and anticonvulsant properties.

Applicazioni

Lidocaine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
Lidocaine may be used as an internal standard in the determination of perhexiline in human serum samples using gas liquid chromatography (GLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Azioni biochim/fisiol

Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Altre note

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAC0142 in the slot below. This is an example certificate only and may not be the lot that you receive.

Prodotti consigliati

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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Pittogrammi

Exclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Certificati d'analisi (COA)

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Simultaneous determination of tolperisone and lidocaine by high performance liquid chromatography
Liawruangrath S, et al.
Journal of Pharmaceutical and Biomedical Analysis, 26(5-6), 865-872 (2001)
Stability indicating HPLC method for the estimation of oxycodone and lidocaine in rectal gel
Gebauer MG, et al.
International Journal of Pharmaceutics, 223(1-2), 49-54 (2001)
A rapid method for the determination of perhexiline in serum using gas-liquid chromatography
CooperHDJ and Turnell CD
Annals of Clinical Biochemistry, 17, 155-158 (1980)
High-performance liquid chromatographic method for the simultaneous determination of lidocaine and its N-dealkylated metabolites in plasma
Nation.LR, et al.
Journal of Chromatography. B, Biomedical Applications, 162, 466-473 (1979)
Development and validation of RP-HPLC method for cetrimonium bromide and lidocaine determination.
Malenovic A, et al.
Il Farmaco (Societa Chimica Italiana : 1989), 60(2), 157-161 (2005)

Articoli

The benefit of HILIC over traditional reversed-phase chromatography is two-fold for both sample introduction and analyte detection. First, the high acetonitrile concentration of HILIC mobile phases allows for direct analysis of precipitated plasma samples without the need for additional sample solvent exchange. Second, the high acetonitrile content provides increased analyte response in positive ESI MS detection.

Contenuto correlato

HILIC mobile phases consist of a high composition of acetonitrile, which facilitates the direct analysis of precipitated plasma samples without the need for additional sample solvent exchange.

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