B5887

Sodium butyrate

≥98.5% (GC)

• Sinonimo/i: Butyric acid sodium salt
• Formula condensata: CH₃CH₂CH₂COONa
• Numero CAS: 156-54-7
• Peso molecolare: 110.09
• Beilstein: 3629439
• Numero CE: 205-857-6
• Numero MDL: MFCD00002816
• Codice UNSPSC: 12352107
• ID PubChem: 24891873
• NACRES: NA.25

Proprietà

• Origine biologica: synthetic (organic)
• Livello qualitativo: 200
• Saggio: ≥98.5% (GC)
• Forma fisica: powder
• Condizioni di stoccaggio: (Tightly closed. Dry.; Keep in a dry place. )
• tecniche: DNA amplification: suitable; cell based assay: suitable; inhibition assay: suitable
• Colore: white
• Punto di fusione: 250-253 °C (lit.)
• Solubilità: water: 100 mg/mL, clear to slightly hazy, colorless
• Cationi in tracce: Na: 19.8-22.0% (anhydrous)
• Compatibilità: suitable for DNA precipitation
• applicazioni: cell analysis; life science and biopharma; lipidomics
• Temperatura di conservazione: room temp
• Stringa SMILE: [Na+].CCCC([O-])=O
• InChI: 1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1; MFBOGIVSZKQAPD-UHFFFAOYSA-M
• Informazioni sul gene: mouse ... ENSMUSG00000061062(15181)

Descrizione

Applicazioni

Sodium butyrate has been used:

• as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
• as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
• to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.

Azioni biochim/fisiol

Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca²⁺ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.

Avvertenza

Hygroscopic

Altre note

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Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H315,H319
• Consigli di prudenza: P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves