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A0152000

Acetylcysteine impurity C

European Pharmacopoeia (EP) Reference Standard

Sinonimo/i:

N,N′-Diacetyl-L-cystine, NSC 203780

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About This Item

Formula empirica (notazione di Hill):
C10H16N2O6S2
Numero CAS:
Peso molecolare:
324.37
Numero CE:
Codice UNSPSC:
41116107
NACRES:
NA.24

Grado

pharmaceutical primary standard

Famiglia di API

acetylcysteine

Produttore/marchio commerciale

EDQM

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-8°C

InChI

1S/C10H16N2O6S2/c1-5(13)11-7(9(15)16)3-19-20-4-8(10(17)18)12-6(2)14/h7-8H,3-4H2,1-2H3,(H,11,13)(H,12,14)(H,15,16)(H,17,18)
YTPQSLLEROSACP-UHFFFAOYSA-N

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the issuing Pharmacopoeia.

For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia. Their suitability for any other use is not guaranteed and is the sole responsibility of the user. This standard is not intended for human or animal use.
Established for the preparation of reference solution (c) in testing for related substances in acetylcysteine using liquid chromatography (General text 2.2.29), according to the monograph 0967 of European Pharmacopeia.

Confezionamento

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Altre note

Sales restrictions may apply.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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L-cisteina European Pharmacopoeia (EP) Reference Standard

C3290000

L-cisteina

Glutaraldeide Grade I, 70% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use

Sigma-Aldrich

G7776

Glutaraldeide

L-Cistina ≥98% (TLC), crystalline

Sigma-Aldrich

C8755

L-Cistina

L-cisteina 97%

Sigma-Aldrich

168149

L-cisteina

M Wågberg et al.
The Journal of pharmacology and experimental therapeutics, 299(1), 76-82 (2001-09-19)
Oxidation of lipoprotein-derived lipids is generally accepted to be important in atherogenesis, and lipophilic antioxidants have been suggested as potential antiatherosclerotic agents. The antiatherogenic effects observed by certain antioxidants, especially probucol, in different animal models support this suggestion. There are
Knut Pettersson et al.
Atherosclerosis, 196(1), 275-282 (2006-12-13)
To investigate if the immunomodulator drug DINAC (1) affects arterial dimensions in asymptomatic patients with hypercholesterolemia, (2) has effects on leucocyte markers of inflammation and (3) has in vitro effects on nitric oxide synthase (NOS) in human umbilical vein endothelial
B Särnstrand et al.
The Journal of pharmacology and experimental therapeutics, 288(3), 1174-1184 (1999-02-23)
Oral N-acetyl-L-cysteine (NAC) is used clinically for treatment of chronic obstructive pulmonary disease. NAC is easily oxidized to its disulfide. We show here that N,N'-diacetyl-L-cystine (DiNAC) is a potent modulator of contact sensitivity (CS)/delayed type hypersensitivity (DTH) reactions in rodents.
Pei Wang et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 39(10), 782-786 (2005-02-11)
To study the therapeutic effects of N,N'-diacetyl-L-cystine (DiNAC) on immunological liver failure. Serum ALT, AST and T cell subsets in peripheral blood of the experimental animals during the trial period were analyzed by an automatic serum analyzer and a flow
Sheila A Doggrell
Expert opinion on investigational drugs, 11(5), 717-720 (2002-05-09)
Not all antioxidants reduce atherosclerosis. This may be because atherosclerosis has an autoimmune, inflammatory pathogenesis. As probucol is both an antioxidant and an immunomodulatory drug, it may be the immunomodulatory effect that underlies its ability to reduce atherosclerosis. N,N-Diacetyl-L-cystine is

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