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Key Documents

75281

Supelco

N-Nitrosoanatabine

analytical standard

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About This Item

Formula empirica (notazione di Hill):
C10H11N3O
Numero CAS:
Peso molecolare:
189.21
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

Saggio

≥97.0% (HPLC)

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable
solid phase extraction (SPE): suitable

applicazioni

cleaning products
cosmetics
food and beverages
personal care

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

O=NN1CC=CCC1c2cccnc2

InChI

1S/C10H11N3O/c14-12-13-7-2-1-5-10(13)9-4-3-6-11-8-9/h1-4,6,8,10H,5,7H2
ZJOFAFWTOKDIFH-UHFFFAOYSA-N

Descrizione generale

Standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706031. N-Nitrosoanatabine (NAT), classified in the third group of carcinogens, belongs to the class of tobacco-specific nitrosamines (TSNAs). TSNAs are carcinogenic compounds, formed through the burning, curing and fermentation of tobacco leaves. Their levels in tobacco can vary and significantly correlate to the amount of nitrate in tobacco. NAT is produced together with N′-nitrosonornicotine [NNN] and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone [NNK]) in tobacco. It can be detected in E-cigarette cartridges, mainstream tobacco smoke, snuff, etc.

Applicazioni

N-Nitrosoanatabine has been used as an analytical reference standard for the quantification of the analyte in urine samples using SupelMIP solid phase extraction (SPE) followed by liquid chromatography coupled to mass spectrometry (LC-MS). It may also be used as an analytical reference standard for the quantification of the analyte in human urine samples, replacement liquids of electronic cigarettes, snuff samples using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pittogrammi

Skull and crossbones

Avvertenze

Danger

Indicazioni di pericolo

Consigli di prudenza

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Certificati d'analisi (COA)

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Adrian A Franke et al.
Drug testing and analysis, 8(10), 1095-1099 (2015-12-02)
Approximately 600 million people worldwide practise the carcinogenic habit of betel nut/quid chewing. Carcinogenic N-nitroso compounds have been identified in saliva or urine of betel chewers and the betel alkaloid arecoline in hair from habitual betel quid chewers. However, the
N-Nitroso compounds in cigarette tobacco and their occurrence in mainstream tobacco smoke
Tricker RA, et al.
Carcinogenesis, 12(2), 257-261 (1991)
Tobacco Control, An Issue of Nursing Clinics-E-Book, 47(1) (2012)
Analytical method for measurement of tobacco-specific nitrosamines in E-cigarette liquid and aerosol
Lee S-Y, et al.
Applied Sciences, 8(12), 2699-2699 (2018)
Analysis of tobacco-specific N-nitrosamines in snuff by ethyl acetate extraction and liquid chromatography-tandem mass spectrometry
Jansson C, et al.
Journal of Chromatography A, 1008(2), 135-143 (2003)

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