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68899

Supelco

Ibuprofen acyl-β-D-glucuronide

analytical standard

Sinonimo/i:

Ibuprofen glucuronide

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About This Item

Formula empirica (notazione di Hill):
C19H26O8
Numero CAS:
115075-59-7
Peso molecolare:
382.40
Numero MDL:
MFCD00871942
Codice UNSPSC:
41116107
ID PubChem:
329761208
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

100

Saggio

≥92% (HPLC)

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

forensics and toxicology
pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

−20°C

Stringa SMILE

CC(C)Cc1ccc(cc1)C(C)C(=O)O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O

InChI

1S/C19H26O8/c1-9(2)8-11-4-6-12(7-5-11)10(3)18(25)27-19-15(22)13(20)14(21)16(26-19)17(23)24/h4-7,9-10,13-16,19-22H,8H2,1-3H3,(H,23,24)/t10?,13-,14-,15+,16-,19-/m0/s1
ABOLXXZAJIAUGR-JPMMFUSZSA-N

Applicazioni

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
BCCG2533
BCCC9070
BCCB5816
BCCB3896
BCBZ6786

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Stephen J Vanderhoeven et al.
Journal of pharmaceutical and biomedical analysis, 41(3), 1002-1006 (2006-02-18)
The products arising from the intra-molecular acyl migration reactions of drug ester glucuronides can be reactive towards cellular proteins and have been proposed to cause toxic side effects. The relative reactivity of a range of drug and model glucuronides have
Robert W Smith et al.
Journal of chromatography. A, 1278, 76-81 (2013-01-23)
The incorporation of a chip-based high field asymmetric waveform ion mobility spectrometry (FAIMS) separation in the ultra (high)-performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) determination of the (R/S) ibuprofen 1-β-O-acyl glucuronide metabolite in urine is reported. UHPLC-FAIMS-HRMS reduced matrix chemical
Atsushi Kawase et al.
The Journal of pharmacology and experimental therapeutics, 356(2), 366-374 (2015-12-15)
Combined administration of methotrexate (MTX) and nonsteroidal anti-inflammatory drugs (NSAIDs) can result in a decreased systemic clearance of MTX. To date, inhibition of renal uptake via organic anion transporters and efflux via multidrug resistance-associated protein (MRPs) by NSAIDs has been
M Castillo et al.
Clinical pharmacology and therapeutics, 57(6), 636-644 (1995-06-01)
Ibuprofen is an over-the-counter nonsteroidal anti-inflammatory drug with a low incidence of severe adverse reactions. It is metabolized by oxidation to carboxyibuprofen and hydroxyibuprofen and by conjugation to an acyl glucuronide. In vitro studies have indicated that ibuprofen glucuronide is
Masahiro Iwaki et al.
Biological & pharmaceutical bulletin, 40(6), 926-931 (2017-06-02)
Combination therapy of non-steroidal anti-inflammatory drugs (NSAIDs) and methotrexate (MTX) sometimes triggers adverse effects, such as liver injury, renal failure, gastrointestinal disorders, and myelosuppression, owing to the reduction of MTX clearance. Previous reports have suggested that NSAIDs inhibit renal MTX
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