12805

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

≥97.0% (TLC), for peptide synthesis

• Sinonimo/i: PyBOP^®
• Formula condensata: C₁₈H₂₈N₆OP · PF₆
• Numero CAS: 128625-52-5
• Peso molecolare: 520.39
• Beilstein: 3584612
• Numero MDL: MFCD00077411
• Codice UNSPSC: 12352101
• ID PubChem: 329749882
• NACRES: NA.22

Proprietà

• product name: (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate, purum, ≥97.0% (TLC)
• Grado: purum
• Livello qualitativo: 200
• Saggio: ≥97.0% (TLC)
• Forma fisica: solid
• Impiego in reazioni chimiche: reaction type: Coupling Reactions
• Punto di fusione: ~150 °C; 154-156 °C (dec.) (lit.)
• applicazioni: peptide synthesis
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: F[P-](F)(F)(F)(F)F.C1CCN(C1)[P+](On2nnc3ccccc23)(N4CCCC4)N5CCCC5
• InChI: 1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1; VIAFLMPQBHAMLI-UHFFFAOYSA-N

Descrizione

Descrizione generale

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.

Applicazioni

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) may be used in the following studies:

• As coupling reagent in the preparation strategies for peptide-oligonucleotide conjugates.
• Synthesis of structured pure triacylglycerol (TAG) regioisomers.
• As coupling reagent in the synthesis of a 3,5-pyrazolidinedione on soluble polyethylene glycol (PEG) polymer support.
• Synthesis of herceptin- nanoparticles.

Analogue of the BOP coupling reagent which does not form carcinogenic HMPA as by-product.

Note legali

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS07,GHS09
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H317,H410
• Consigli di prudenza: P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352
• Classi di pericolo: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves