11162306001
Roche
ATP-γ-S
=90% (HPLC), solution, pkg of 200 μL (20 μmol)
Sinonimo/i:
adenosine-5′-o-(3-thio-triphosphate)
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About This Item
Codice UNSPSC:
12352204
Prodotti consigliati
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Livello qualitativo
Descrizione
C10H16N5O12P3SLi (Formula)
Lithium salt
Saggio
90% (HPLC)
Forma fisica
solution
PM
523.2
Confezionamento
pkg of 200 μL (20 μmol)
Produttore/marchio commerciale
Roche
λmax
260 nm at 100 mmol/L
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Categorie correlate
Descrizione generale
Adenosine 5′-O-(3-thiotriphosphate), lithium salt, solution.
Applicazioni
ATP-γ-S has been used:
- to treat THP-1 macrophage cell lines for testing if endoplasmic reticulum (ER) stress causes the production of interleukin (IL)-1β
- in amide hydrogen exchange (HX) experiments coupled to mass spectrometry and study the cyclomarin A (CymA)-induced structural changes in NMtb-ClpC
- as a supplement in CMG-binding buffer for gel-based DNA unwinding assays
Azioni biochim/fisiol
Adenosine 5′-O-(3-thiotriphosphate) (ATP-γ-S) is a substrate and inhibitor of ATP-dependent enzyme systems. It is hydrolyzed very slowly by phosphatases and most ATPases. Once thiophosphorylated, proteins are resistant to protein phosphatases. ATP-γ-S serves as a damage-associated molecular pattern molecule (DAMP) and NLR family pyrin domain containing 3 (NLRP3) inflammasome activator. ATP-γ-S may serve as a substrate for RNA-stimulated nucleotide hydrolysis and RNA unwinding activities of eukaryotic initiation factor-4A (eIF4A).
Qualità
Contaminants: ≤10% ADP (HPLC)
Altre note
For life science research only. Not for use in diagnostic procedures.
Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
No data available
Punto d’infiammabilità (°C)
No data available
Certificati d'analisi (COA)
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I clienti hanno visto anche
Alana G Lerner et al.
Cell metabolism, 16(2), 250-264 (2012-08-14)
When unfolded proteins accumulate to irremediably high levels within the endoplasmic reticulum (ER), intracellular signaling pathways called the unfolded protein response (UPR) become hyperactivated to cause programmed cell death. We discovered that thioredoxin-interacting protein (TXNIP) is a critical node in this "terminal UPR."
Michael Maurer et al.
Cell chemical biology, 26(8), 1169-1179 (2019-06-18)
ATP-driven bacterial AAA+ proteases have been recognized as drug targets. They possess an AAA+ protein (e.g., ClpC), which threads substrate proteins into an associated peptidase (e.g., ClpP). ATPase activity and substrate selection of AAA+ proteins are regulated by adapter proteins
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