MABS1922

Anti-Src-Like-Adaptor 2 (SLA2) Antibody, clone Z30P1F12*F4

clone Z30P1F12*F4, from mouse

• Sinonimo/i: Modulator of antigen receptor signaling, MARS, Src-like adapter protein 2, SLAP-2
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.43

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified antibody
• Tipo di anticorpo: primary antibodies
• Clone: Z30P1F12*F4, monoclonal
• Reattività contro le specie: human
• tecniche: immunohistochemistry: suitable (paraffin)
• Isotipo: IgG1κ
• N° accesso NCBI: NP_115590
• N° accesso UniProt: Q9H6Q3
• Condizioni di spedizione: ambient
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... SLA2(84174)

Descrizione

Descrizione generale

Src-like-adapter 2 (UniProt: Q9H6Q3; also known as Modulator of antigen receptor signaling; MARS; Src-like adapter protein 2; SLAP-2) is encoded by the SLA2 (also known as SLAP2, C20orf156) gene (Gene ID 84174) in human. SLAP-2 is localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles. The SLAP-2 protein contains an NH2-terminal myristoylation consensus sequence and SH3 and SH2 Src homology domains, but lacks a tyrosine kinase domain. It is predominantly expressed in immune system, including T cells and monocytes and at low levels in B cells, placenta, prostate, colon, and skin. SLAP-2 serves as an adapter protein that negatively regulates T-cell receptor (TCR) signaling and is shown to block T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. In antigen receptor-stimulated cells, SLAP-2 associates with several tyrosine phosphorylated proteins, including the ubiquitin ligase Cbl. Deletion of the carboxyl terminus of SLAP-2 is shown to block its function and abolish its association with Cbl. Overexpression of SLAP-2 in T and B cell lines impairs antigen receptor-mediated signaling events, including the up-regulation of CD69, NFAT promoter activation, and calcium influx. Ref.: Holland, SJ et al. (2001). J. Exp. Med. 194(9):1263-1276. Pandey, A., et al. (2002). J. Biol. Chem. 277(21):19131-19138.

Specificità

Clone Z30P1F12*F4 detects -Src-Like-Adaptor 2 (SLA2) protein in human by targeting a sequence in the C-terminal region.

Immunogeno

A synthetic peptide corresponding to 8 aa from the C-terminal region of human Src-like adapter 2 protein.

Applicazioni

Detect Src-like-adapter 2 using this mouse monoclonal Anti-Src-Like-Adaptor 2 (SLA2) antibody, clone Z30P1F12*F4, Cat. No. MABS1922, validated for use in Immunohistochemistry (Paraffin).

Research Category
Signaling

Qualità

Evaluated by Immunohistochemistry in human cervical cancer, pancreas, and tonsil tissue.

Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Src-Like-Adaptor 2 (SLA2) in human cervical cancer, pancreas, and tonsil tissue.

Descrizione del bersaglio

28.6 kDa calculated.

Stato fisico

Format: Purified

Protein G purified

Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Altre note

Concentration: Please refer to lot specific datasheet.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1