MABC200
Anti-APC Antibody, clone CC-1
clone CC-1, from mouse
Sinonimo/i:
Adenomatous polyposis coli protein, APC, Deleted in polyposis 2.5
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
CC-1, monoclonal
Reattività contro le specie
human
tecniche
immunohistochemistry: suitable
Isotipo
IgG2bκ
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... APC(324)
Descrizione generale
Adenomatous polyposis coli protein (APC) is a ubiquitous multidomain protein that has a well documented role as a tumor suppressor. The mechanism of APC-mediated tumor suppression is still an area of active investigation; however, several studies suggest that APC is a negative regulator of the Wnt signaling pathway as it downregulates β-catenin via interactions with Axin/GSK3-β complex, thereby preventing transcription of genes such as MYC that contribute to cell proliferation. Defective APC proteins contribute to the initiation and proliferation of various types of cancers, including familial adenomatous polyposis. However, other studies have shown that APC interacts with a range of other proteins such as the EB1 microtubule-binding proteins, to regulate other processes such as cell migration.
Immunogeno
Recombinant protein corresponding to human APC.
Applicazioni
Anti-APC Antibody, clone CC-1 detects levels of APC proteins & has been published & validated for use in IHC.
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected APC in human brain tissue containing multiple schlerosis lesions (Saikali, P. et al. (2007). J Neurosci. 27(5):1220-1228.).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected APC in rat spinal cord injury tissue (McTique, D. M., et al. (2001). J Neurosci. 21(10):3392-3400.).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected APC in rat spinal cord injury tissue (McTique, D. M., et al. (2001). J Neurosci. 21(10):3392-3400.).
Qualità
Immunohistochemistry Analysis: A 1:5 dilution from a representative lot detected APC in human colorectal cancer tissue, human smooth muscle tissue, and human colon tissue.
Descrizione del bersaglio
311 kDa calculated
Stato fisico
Format: Purified
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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Emily G Baxi et al.
Glia, 62(9), 1513-1529 (2014-05-28)
Nerve conduction within the mammalian central nervous system is made efficient by oligodendrocyte-derived myelin. Historically, thyroid hormones have a well described role in regulating oligodendrocyte differentiation and myelination during development; however, it remains unclear which thyroid hormone receptors are required
Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord.
McTigue, D M, et al.
The Journal of Neuroscience, 21, 3392-3400 (2001)
Bastian G Brinkmann et al.
Neuron, 59(4), 581-595 (2008-09-02)
Understanding the control of myelin formation by oligodendrocytes is essential for treating demyelinating diseases. Neuregulin-1 (NRG1) type III, an EGF-like growth factor, is essential for myelination in the PNS. It is thus thought that NRG1/ErbB signaling also regulates CNS myelination
Kee-Yong Ha et al.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 17(6), 864-872 (2008-03-21)
The over-expression of excitotoxic neurotransmitter, such as glutamate, is an important mechanism of secondary injury after spinal cord injury. The authors examined the neuroprotective effect of pregabalin (GP) which is known as to reduce glutamate secretion, in a rat model
Qi-Yan Cai et al.
Anatomical record (Hoboken, N.J. : 2007), 292(4), 498-512 (2009-01-15)
The tumor suppressor phosphatase and tensin homologue (PTEN) is a protein and lipid phosphatase. PTEN mutations have been associated with a large number of human cancers. To understand the physiological role of PTEN in the brain and its relationship to
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