Passa al contenuto
Merck
Tutte le immagini(3)

Documenti fondamentali

MABS1911

Sigma-Aldrich

Anti-Serpin B9 Antibody, clone 7D8

clone 7D8, from mouse

Sinonimo/i:

Cytoplasmic antiproteinase 3, CAP-3, CAP3, Peptidase inhibitor 9, PI-9

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali


About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

7D8, monoclonal

Reattività contro le specie

human

Confezionamento

antibody small pack of 25 μL

tecniche

ELISA: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

Isotipo

IgG1κ

N° accesso NCBI

N° accesso UniProt

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... SERPINB9(5272)

Descrizione generale

Serpin B9 (UniProt: P50453; also known as Cytoplasmic antiproteinase 3, CAP-3, CAP3, Peptidase inhibitor 9, PI-9) is encoded by the SERPINB9 (also known as PI9) gene (Gene ID: 5272) in human. Serpins serve as intracellular or extracellular regulators of a wide range of physiological processes such as complement activation, blood coagulation and apoptosis. Within the vertebrate immune system, they control proteases of the classical and innate complement systems, and are also potent inhibitors of many leukocyte granule proteases. Serpin B9 has a broad tissue distribution, being present at high and relatively stable levels natural killer cells and CD8+ T cells, antigen-presenting cells, in many endothelial and mesothelial cells and at sites of immune privilege such as testis and placenta. Serpin B9 serves as a regulator granzyme B activity by acting as an inhibitor of its activity. Overexpression of Serpin B9 may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. Certain tumors may upregulate Serpin B9 levels as a mechanism of immune evasion. (Ref.: Kaiserman, D., and Bird, PI (2010). Cell Death Differen. 17(4); 586-595).

Specificità

Clone 7D8 detects Serpin B9 in human cells.

Immunogeno

His-tagged full length human recombinant Serpin B9.

Applicazioni

Anti-Serpin B9, clone 7D8, Cat. No. MABS1911, is a mouse monoclonal antibody that detects Serpin B9 and has been tested for use in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunofluorescence, and Western Blotting.
ELISA Analysis: A representative lot detected Serpin B9 in ELISA applications (Hirst, C.E., et. al. (2001). Mol Hum Peprod. 7(12):1133-42).

Flow Cytometry Analysis: A representative lot detected Serpin B9 in Flow Cytometry applications (Hirst, C.E., et. al. (2003). J Immunol. 170(2):805-15).

Immunocytochemistry Analysis: A representative lot detected Serpin B9 in Immunocytochemistry applications (Hirst, C.E., et. al. (2003). J Immunol. 170(2):805-15).

Immunofluorescence Analysis: A representative lot detected Serpin B9 in Immunofluorescence applications (Hirst, C.E., et. al. (2003). J Immunol. 170(2):805-15).

Immunohistochemistry Analysis: A representative lot detected Serpin B9 in Immunohistochemistry applications (Hirst, C.E., et. al. (2001). Mol Hum Peprod. 7(12):1133-42).

Western Blotting Analysis: A 1:100 dilution from a representative lot detected Serpin B9 in YT and Jurkat cell lysates (Courtesy of Prof. Phillip Bird, Ph.D., Monash University, Victoria Australia).

Western Blotting Analysis: A representative lot detected Serpin B9 in Western Blotting applications (Hirst, C.E., et. al. (2001). Mol Hum Peprod. 7(12):1133-42; Hirst, C.E., et. al. (2003). J Immunol. 170(2):805-15; Mangan, M.S., et. al. (2015). J Biol Chem. 291(7):3626-38).

Immunocytochemistry Analysis: A representative lot detected Serpin B9 in COS-1 cells (Courtesy of Prof. Phillip Bird, Ph.D., Monash University, Victoria Australia).
Research Category
Inflammation & Immunology

Qualità

Evaluated by Immunohistochemistry in human spleen tissue sections.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Serpin B9 in human spleen tissue sections.

Descrizione del bersaglio

42.40 kDa calculated.

Stato fisico

Format: Purified
Protein G purified
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Altre note

Concentration: Please refer to lot specific datasheet.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Non trovi il prodotto giusto?  

Prova il nostro Motore di ricerca dei prodotti.

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.