MABN787

Anti-Dual oxidase 2, clone Duox S-12 Antibody

clone Duox S-12, from mouse

• Sinonimo/i: Dual oxidase 2, Large NOX 2, Long NOX 2, NADH/NADPH thyroid oxidase p138-tox, NADPH oxidase/peroxidase DUOX2, NADPH thyroid oxidase 2, Thyroid oxidase 2, p138 thyroid oxidase
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: Duox S-12, monoclonal
• Reattività contro le specie: human
• tecniche: immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• Isotipo: IgG1κ
• N° accesso NCBI: NP_054799
• N° accesso UniProt: Q9NRD8
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... DUOX2(50506)

Descrizione

Descrizione generale

Dual oxidase 2 is an important enzyme in thyroid hormone biosynthesis and peroxide metabolism. Dual oxidase 2 generates the hydrogen peroxide needed for thyroid peroxidase and lactoperoxidase enzymes as well as processes H2O2 made during metabolic processes. Dual oxidase also plays a role in anti-microbial defense in our mucous membranes by providing the peroxidase for lactoperoxidase’s antimicrobial activities. Dual oxidase 2 is also needed for various extracellular matrix stabilizations and protein cross-linking needs such as during cuticle formation. Dual oxidase 2 is widely expressed in the developing fetus, and in the adult, it is largely expressed in the mucosal and epithelial cells and linings of the gut, lung, salivary glands and testis. Dual oxidase also plays a role in many hypersensitivity and inflammatory diseases and is upregulated in diseases such as colitis and certain cancers.

Immunogeno

Epitope: N-terminus

Recombinant protein corresponding to the N-terminus of human Dual oxidase 2.

Applicazioni

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Dual oxidase 2 in human prostate cancer and human breast cancer tissue.
Western Blotting Analysis: A representative lot detected Dual oxidase 2 in BxPC-3 cell lysate (Wu, Y., et al. (2013). International Journal of Oncology. 42:1229-1238).
Immunocytochemistry Analysis: A representative lot detected Dual oxidase 2 in MIA PACA-2 cell (Wu, Y., et al. (2013). International Journal of Oncology. 42:1229-1238).
Immunohistochemistry Analysis: A representative lot detected Dual oxidase 2 MIA PACA-2 tissue (Wu, Y., et al. (2013). International Journal of Oncology. 42:1229-1238).

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

This Anti-Dual oxidase 2, clone Duox S-12 Antibody is validated for use in Western Blotting and Immunohistochemistry and Immunocytochemistry for the detection of Dual oxidase 2.

Qualità

Evaluated by Western Blotting in BxPC3 treated with IL-4 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Dual oxidase 2 in 10 µg of BxPC3 treated with IL-4 cell lysate.

Descrizione del bersaglio

~175 kDa observed

Stato fisico

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Altre note

Concentration: Please refer to lot specific datasheet.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable