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Key Documents

MAB1987

Sigma-Aldrich

Anti-Integrin β1 Antibody, clone P4C10

culture supernatant, clone P4C10, Chemicon®

Sinonimo/i:

CD29

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

Forma dell’anticorpo

culture supernatant

Tipo di anticorpo

primary antibodies

Clone

P4C10, monoclonal

Reattività contro le specie

human

Produttore/marchio commerciale

Chemicon®

tecniche

ELISA: suitable
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG2a

N° accesso UniProt

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... ITGB1(3688)

Specificità

Reacts with the beta-1 subunit of the integrin protein family. Appears to be human specific. Unlike many beta-1 monoclonals 4C10′s epitope is not trypsin sensitive.

Applicazioni

Detect Integrin β1 using this Anti-Integrin β1 Antibody, clone P4C10 validated for use in ELISA, IP, WB & IC.
Inhibits attachment of UCLA-P3 cells to collagen type I (Wayner, 1991). Inhibits endodermal and keratinocytes to collagen, fibronectin and laminin. It also inhibits cell to cell adhesion. Typical dilution ranges are 1:50-1:500.

Immunoflourescence

Immunoblotting

Immunoprecipitation

ELISA

Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected Integrin β1 in HeLa cells.

Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Research Sub Category
Integrins

Stato fisico

Tissue Culture supernatant, containing 0.1% sodium azide.

Stoccaggio e stabilità

Maintain frozen at -20°C in undiluted aliquots for up to 12 months.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Raccomandato

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Morgan Dos Santos et al.
Aging, 8(4), 751-768 (2016-03-22)
The epidermis is continuously renewed by stem cell proliferation and differentiation. Basal keratinocytes append the dermal-epidermal junction, a cell surface-associated, extracellular matrix that provides structural support and influences their behaviour. It consists of laminins, type IV collagen, nidogens, and perlecan
Sandy Mosig et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(3), 866-874 (2008-11-13)
The study was undertaken to investigate whether the two major monocyte subsets defined by the surface markers CD14(+)CD16(+) and CD14(++)CD16(-) show differences in their responses to hypercholesterolemia. Monocytes were rapidly isolated from the blood of hypercholesterolemic, low-density lipoprotein (LDL) receptor-defective
M Fornaro et al.
Molecular biology of the cell, 11(7), 2235-2249 (2000-07-11)
The integrin cytoplasmic domain modulates cell proliferation, adhesion, migration, and intracellular signaling. The beta(1) integrin subunits, beta(1C) and beta(1A), that contain variant cytoplasmic domains differentially affect cell proliferation; beta(1C) inhibits proliferation, whereas beta(1A) promotes it. We investigated the ability of
Cytoskeletal mechanics in adherent human airway smooth muscle cells: probe specificity and scaling of protein-protein dynamics.
Puig-de-Morales, M; Millet, E; Fabry, B; Navajas, D; Wang, N; Butler, JP; Fredberg, JJ
American Journal of Physiology. Cell Physiology null
Integrin receptors play a role in the internalin B-dependent entry of Listeria monocytogenes into host cells.
Clementina Auriemma,Maurizio Viscardi,Simona Tafuri,Luigi Michele Pavone,Federico Capuano et al.
Cellular & Molecular Biology Letters null

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